The Danish start-up has developed a complement that enhances intestine well being and mitochondrial exercise by combining pomegranate extract with Human Milk Oligosaccharides (HMOs), a patent-pending components.
Ellagitannins present in pomegranate peel rework into urolithins through intestine microbiota, facilitating mitophagy—the clearance of broken mitochondria—to help the era of recent mitochondria.
Nevertheless, as Mads Bjørnhof, chief industrial officer, defined to NutraIngredients, roughly 50% of people over the age of 40 wrestle to supply ample urolithin A.
As urolithin A manufacturing is restricted by the particular bacterial strains current in a person’s intestine, in addition to the general well being and composition of their microbiome, there’s a necessity for urolithin A options.
“By naturally enhancing urolithin manufacturing, Migalis seeks to enhance the intestine well being, mobile operate and vitality ranges of a variety of the inhabitants,” he mentioned.
Mixed forces
The beginning-up was born from the possibility assembly of two co-founders from completely different fields, Leif Helth Jensen and Ina Giversen. Jensen was the primary CEO of Glycom, the HMO producer that was acquired by DSM in 2020. Giversen had a background in dietary supplements and based male fertility complement model Punalpin utilizing pomegranate-based merchandise.
Punicalagins are polyphenolic compounds liable for lots of the well being advantages related to pomegranate, due to their antioxidant, anti-inflammatory and antimicrobial properties.
The challenges in changing pomegranate into urolithin A resulting from intestine microbiome limitations sparked their joint curiosity in exploring the mix of HMOs with pomegranate extract to stimulate intestine micro organism for environment friendly urolithin A manufacturing.
In vitro and human research revealed that the mix might improve urolithin A manufacturing in people with suboptimal intestine microbiomes. From there, the founders developed the product combining HMOs and a high-punicalagin pomegranate extract.
“HMOs are selective of their motion, stimulating solely the helpful micro organism with out the negative effects that another prebiotics might need,” Bjørnhof mentioned.
Blends to spice up athlete intestine well being
Migalis ApS now focuses its consideration on endurance athletes, providing the product in dissolvable powder blends for comfort.
This method aligns with the corporate’s broader aim of optimizing well being by means of intestine microbiome and mitochondrial help, focusing on areas like sports activities vitamin whereas exploring additional purposes akin to wholesome growing old.
Mitophagy helps stop the buildup of dangerous reactive oxygen species (ROS) and maintains the effectivity of vitality manufacturing.
This, Bjørnhof defined, is crucial within the context of sports activities vitamin, as it might improve athletic efficiency and restoration by selling muscle well being and lowering irritation.
“A excessive share of endurance athletes, particularly in ultra-running and triathlons, face extreme GI points throughout extended intense train,” he mentioned. “These disruptions considerably have an effect on coaching and efficiency.
The Migalis answer goals to deal with these intestine points to the good thing about many endurance athletes.
“Moreover, by enhancing mitochondrial well being, we are able to improve vitality availability, scale back muscle fatigue, and shorten restoration occasions.”
Constructing client belief by means of neighborhood
Bjørnhof mentioned {that a} main problem for Migalis lies in transitioning from a technological platform to a focused client model.
“The well being area is intricate, with rising client consciousness of phrases like probiotics and prebiotics, necessitating clear and targeted messaging that highlights the worth to the buyer,” he famous.
The corporate has deliberately delayed full commercialization with a view to prioritize community-building and ongoing dialogue with lead customers.
“Our neighborhood shares suggestions, helps refine communication methods, and educates others,” Bjørnhof mentioned.
“We rely on their engagement to shut gaps, keep related with customers and construct belief and credibility as we navigate laws.”
Bjørnhof might be presenting Migalis ApS on stage throughout the IPA world congress + Probiota 2025, to be held in Copenhagen from Feb. 5 to 7.
