The Swedish life science tech firm has launched the EpiFinder GenomePro to reinforce researchers’ capacity to find biomarkers, perceive illness mechanisms and develop precision therapies inside shorter time scales.
Powered by the Epigenomica AB’s patented high-throughput, multiplex, quantitative Chromatin Immunoprecipitation Sequencing (ChIP-seq) know-how, the brand new platform makes large-scale research “extra accessible than ever” because of the diminished price per pattern.
“With EpiFinder GenomePro, we’re setting a brand new customary in epigenomic analysis,” mentioned Mohamad Takwa, CEO of Epigenica AB. “Our imaginative and prescient is to offer a platform that delivers useful insights, enabling researchers to sort out complicated organic questions with unprecedented scale and depth.”
The device permits the evaluation of histone post-translational modifications (hPTMs) and DNA methylation—the foundations of epigenetic regulation of gene expression, chromatin construction and mobile identification—concurrently, and sooner than earlier than because of its optimized reagents.
Researchers can acquire sturdy quantitative information for 192 genome-wide ChIP-Seq profiles for a number of hPTMs and DNA methylation from minimal pattern volumes.
Takwa mentioned it presents “unparalleled excessive throughput and cost-efficiency, whereas sustaining distinctive information high quality” in addition to information transparency and reproducibility.
Boundaries to epigenomic analysis
Many business epigenomics applied sciences are restricted by their capacity to profile one or a number of marks and samples at a time, at low throughput and excessive price, the agency explains on its web site.
“As we speak, researchers can display for both DNA methylation (DNAm) or histone post-translational modifications (HPTMs)–however not each concurrently,” it says. “Experiments additionally require many cells to generate correct data. Appreciable enter materials is required to undertake complete, epigenetic screens throughout a number of samples and a number of epigenetic markers, as a result of it’s tough to make quantitative comparisons throughout research or samples, the utility of epigenetic analysis is proscribed.”
The EpiFinder platform is described as a “first-in-class” multiplexed ChIP-seq know-how for high-throughput evaluation of epigenetic marks that lets scientists discover epigenetic biomarkers with “unprecedented pace, scalability, and affordability.”
Epigenomic analysis and diet
Epigenetic modifications are modifications to DNA that regulate whether or not genes are turned up or turned down. Epigenetic testing permits the research of how weight loss plan and setting modifications the way in which an individual’s genes work.
Epigenetic modifications embody DNA methylation, histone modification and non-coding RNA exercise.
Histone post-translational modifications (hPTMs) are chemical modifications made to histone proteins after they’re produced. These modifications play an important function in regulating gene expression by altering how tightly DNA is wrapped round histones, which impacts whether or not genes are turned “on” or “off”.
DNA methylation modifications how genes are expressed and patterns change over time so can be utilized as organic age markers. Eating regimen performs a big half on this. For instance, sure plant compounds comparable to curcumin and resveratrol might inhibit DNA methyltransferases (DNMTs), probably reversing irregular methylation patterns.
Epigenomic insights assist determine bioactive compounds that may modulate gene expression. For instance, curcumin, resveratrol, sulforaphane, and EGCG (from green tea) have the potential to influence DNA methylation and histone acetylation, probably impacting irritation and growing older.
Vitamin D has direct results on the epigenome and the expression of greater than 1,000 genes in most human tissues and cell varieties.
Meals wealthy in methyl donors like folate, B12 and choline can even affect gene silencing and activation. These are being included into prenatal and longevity-focused dietary supplements.
