Researchers from the Beijing College of Chinese language Drugs studied 30 randomized managed trials (RCT) that concerned 44,972 members over 20 years. Their meta-analysis of the information confirmed that dietary supplements can modulate uric acid ranges, oxidative stress and lipid metabolism.
“The outcomes counsel that dietary dietary supplements might function an adjunctive remedy for hyperuricemia and gout,” the they wrote within the journal Diet & Metabolism. “Particularly, a mix of vitamin C (250–500 mg/day) and probiotics is really helpful for managing uric acid ranges, and curcumin is suggested for lipid regulation.”
A drug complement
Hyperuricemia (abnormally excessive uric acid ranges in blood) and gout (a sort of arthritis the place joint ache, redness and swelling happen) are public well being considerations which might be affiliated with comorbidities like heart problems, power kidney illness and metabolic syndrome. Elevated ranges of uric acid might trigger dysfunction of the interior lining of blood and lymphatic vessels and promote oxidative stress, growing heart problems threat.
“The pathogenesis of hyperuricemia is multifaceted, encompassing renal dealing with of uric acid, dietary influences and genetic predisposition,” the researchers defined.
“The kidneys are integral to the excretion of uric acid, with roughly two-thirds of uric acid being eradicated by way of renal pathways. Alterations within the reabsorption and secretion processes of uric acid by the renal tubules can affect the danger of growing gout.”
Managing hyperuricemia and gout requires medicine like allopurinol and febuxostat. These drugs forestall gout assaults by blocking the formation of uric acid crystals. Nevertheless, dietary dietary supplements might also handle gout as analysis reveals weight loss program can affect the prevalence of the situation. For instance, the Mediterranean weight loss program diminishes cardiovascular threat components, providing a protecting impact in individuals with gout.
The researchers recommended that dietary supplements might “successfully complement pharmacological interventions geared toward decreasing uric acid ranges and improve the standard of life for sufferers experiencing hyperuricemia.”
Research particulars
Probiotics demonstrated appreciable potential in lowering gout recurrence, adopted by DKB114—a combination of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark extracts—and vitamin C.
The researchers additionally investigated the Malondialdehyde (MDA) ranges in research members handled with dietary dietary supplements. MDA is a marker of oxidative stress. In that context, two dietary dietary supplements—nutritional vitamins C and E— confirmed important benefits when it comes to imply variations in MDA ranges over standard drug therapy or placebo. The research additionally discovered {that a} mixture of vitamin B12 and folic acid demonstrates efficacy in lowering MDA content material.
Concerning low-density lipoprotein (LDL) ranges in members receiving dietary dietary supplements, the researchers famous that “curcumin exhibited important benefits over vitamin E, vitamin C and cherries, with variations reaching statistical significance” and that ”curcumin seems to be the best remedy for lowering low-density lipoprotein ranges in sufferers with hyperuricemia.” This was adopted by DKB114, which additionally emerged as one of the best remedy to scale back triglycerides in members with hyperuricemia.
A subgroup evaluation demonstrated vitamin C with xanthine oxidase and tea polyphenols notably decreased serum uric acid ranges in members when in comparison with standard remedy alone.
The researchers then analyzed bitter cherry juice and cherry powder capsules, and so they discovered that “the juice considerably elevated uric acid ranges in comparison with the placebo, whereas the capsule kind confirmed no important impact.”
“This discrepancy could also be attributed to the reliance of strong dietary supplements, comparable to cherry powder capsules, on gastrointestinal disintegration and interactions with excipients,” they added recommended. “Particularly, starch-based fillers inside capsules might dilute the energetic compounds, comparable to anthocyanins, thereby lowering their bioavailability.”
Though the researchers had been in a position to establish which dietary supplements have probably the most efficacy underneath sure organic situations, they recommended that longitudinal RCTs will help decide supreme dosage, formulation and suitability for particular populations. This consists of pregnant girls and other people with renal insufficiency.
Supply: Diet & Metabolism. doi: doi.org/10.1186/s12986-025-00977-2. “The effectiveness and security of particular dietary dietary supplements in modulating uric acid ranges, oxidative stress, and lipid metabolism in sufferers: a community meta-analysis of 13 interventions”. Authors: Guancheng Ye et al.
