In a current examine funded by life sciences firm ABbiotek Well being, researchers from Spain investigated the consequences of yeast-based postbiotic mix ABB C22 on gastrointestinal well being. The formulation combines Saccharomyces boulardii ABB S3, Saccharomyces cerevisiae ABB S6 and Kluyveromyces marxianus ABB S8
“This novel method to managing diarrhea by enhancing the related gastrointestinal irritation, which present options don’t tackle,” they wrote within the journal Geriatrics.
In contrast to typical therapies, the ABB C22 postbiotic was discovered to help the integrity and performance of enterocytes via a number of complementary mechanisms. These embrace enhancing intestine barrier perform, inducing a powerful anti-inflammatory response, defending in opposition to rotavirus an infection and modulating the intestine microbiome.
Diarrhea influence on aged populations
Diarrhea is a typical situation in older adults that may result in dehydration and malnutrition, impair intestine barrier perform and negatively impact quality of life. It’s predominantly attributable to infections, resembling Clostridium difficile, E. coli and rotavirus.
Power diarrhea, which may final over 4 weeks, could consequence from underlying well being circumstances or as a facet impact of medicines—significantly antibiotics, that are commonly prescribed to older adults. Antibiotic-associated diarrhea happens when antibiotics disrupt the intestine microbiome, decreasing useful micro organism and resulting in dysbiosis.
Probiotic strains resembling Saccharomyces boulardii have been discovered to assist manage the symptoms of diarrhea, in addition to irritable bowel syndrome and inflammatory bowel illness. In accordance with the researchers, S. boulardii has a “superior capability to modulate the intestine microbiota and promote the manufacturing of short-chain fatty acids (SCFAs),” resembling butyric acid that promote water reabsorption.
Nevertheless, they famous that “many sufferers on enteral diet applications or affected by acute diarrhea episodes within the hospital setting could also be immunocompromised, which raises considerations for treating them with stay probiotics”.
“Diarrhea-associated irritation has a powerful influence on illness final result, changing into a threat issue for dehydration and episode recurrence,” they wrote.
“Nevertheless, it’s normally uncared for throughout remedy. Present therapies like ORS goal water and electrolyte loss, thus enhancing stool consistency, however are unable to counteract irritation.”
Research particulars
The researchers performed the randomized, double-blind, placebo-controlled, parallel-group trial at two hospital facilities in Barcelona, enrolling 47 volunteers ages 65 and over who have been experiencing diarrhea.
Contributors have been randomly assigned to obtain three each day servings of a 200 ml strawberry-flavored ORS (both with ABB C22 or placebo) for as much as 14 days or till diarrhea resolved.
Blood and stool samples have been collected on days 1, 3 and 14 to evaluate fecal inflammatory biomarkers (calprotectin and lactoferrin), blood immunoglobulin A ranges and modifications in stool consistency utilizing the Bristol Stool Scale.
By the ultimate day of the examine, the group utilizing ORS + ABB C22 confirmed higher reductions in fecal calprotectin and lactoferrin ranges in comparison with the placebo group. By day 3, lactoferrin-positive circumstances had already been halved within the intervention group. Stool consistency improved in each teams.
Elevated fecal calprotectin and lactoferrin are markers of intestinal irritation, with lactoferrin usually related to infectious gastroenteritis.
“The addition of postbiotic ABB C22 to the usual of care with ORS results in decreases in fecal biomarkers of gastrointestinal irritation in older adults with diarrhea,” the researchers wrote. In addition they highlighted that ABB C22 supplies extremely bioavailable zinc, which can assist enhance dietary standing of individuals with diarrhea.
For future analysis, they referred to as for microbiome evaluation and longer follow-up durations to raised perceive the long- time period results and potential advantages of ABB C22.
Supply: Geriatrics 2025, 10(2), 34. doi: 10.3390/geriatrics10020034. “Mitigating Diarrhoea-Associated Irritation in Frail Older Adults with Postbiotic-Enhanced Oral Rehydration Resolution: Insights from a Randomised, Double-Blind, Placebo-Managed Research”. Authors: Rodríguez, A. M. et al.
