“Due to this fact, [olive leaf extract] may be evaluated as an efficient dietary technique to assist girls navigate the postmenopausal years being much less affected by its destructive signs,” wrote scientists from Maastricht College and Solabia Diet within the journal Vitamins.
The examine used the Bonolive model of olive leaf extract, marketed by Solabia Diet within the Netherlands, which gained this yr’s Nutraingredients Innovations in Women’s Health Award.
Bonolive is described as a clinically validated extract from Manzanilla olive leaves, standardized for 40% of the lively ingredient oleuropein. The complement has reported constructive results on bone-formation markers, lowering joint ache and bettering blood lipid profiles in earlier research, that are all key areas in menopausal well being.
How does olive leaf extract have an effect on hormones?
Oleuropein is essentially the most prevalent polyphenol in olive tree leaves, Olea europaea. Its construction resembles oestradiol, and scientists have researched the compound’s skill to compete with estrogen for receptor-binding websites.
Phytoestrogens could bind to estrogen receptor α (Erα) and estrogen receptor β (Erβ). Erα has been linked to breast most cancers cell proliferation, however Erβ has been proven to counteract this.
“Phytoestrogens present a better binding choice for Erβ than for Erα,” the researchers defined.
“Due to this fact, when in comparison with estrogen and HRT, phytoestrogen publicity has been associated to lowered danger of unwanted side effects,” they added, noting that laboratory research demonstrated that oleuropein has this impact.
Postmenopausal advantages
Menopause could cause varied bodily and psychological signs resembling sizzling flashes, anxiousness, despair, decreased sexual perform and decrease bone mineral density.
Hormone substitute remedy (HRT) is prescribed for menopause however could enhance the chance of breast most cancers, stroke or coronary heart illness.
As a pure various to HRT, research counsel that olive leaf extract is useful for sustaining bone mineral density by enhancing the formation of latest bone cells and bettering lipid and ldl cholesterol profiles.
“Our outcomes present that [olive leaf extract] improves lipid dysregulation and may thereby lower the chance of CVD,” the researchers famous.
Research particulars
The randomized, double-blind, placebo-controlled trial recruited 60 wholesome postmenopausal girls between the ages of 47 and 70 who had not used hormone substitute remedy or dietary supplements for 3 months earlier than the examine. They consumed a each day dose of 250 mg of Bonolive olive leaf extract (OLE) from Spanish Manzanilla olive leaves or placebo for 12 weeks.
The intervention dose was primarily based on earlier analysis evaluating Bonolive’s impact on lipid profiles and bone well being in postmenopausal girls.
Researchers assessed contributors at baseline, six weeks, and 12 weeks utilizing blood samples, DEXA scan, Menopause High quality of Life questionnaire (MENQoL), handgrip power and the Worldwide Bodily Exercise Questionnaire (IPAQ-L).
The outcomes confirmed that singular vasomotor, psychosocial, bodily and sexual area scores for MENQoL weren’t considerably totally different between teams, however the general MENQoL rating was considerably improved after OLE supplementation in comparison with placebo.
DEXA scans confirmed that bone mineral density in the best arm considerably elevated within the OLE group after 12 weeks in comparison with the placebo group. Constructive tendencies had been noticed within the handgrip power exams, however no important variations existed between teams.
Blood lipid evaluation revealed important decreases in triglycerides and the triglyceride/HDL ldl cholesterol ratio within the OLE group in comparison with placebo.
Supply: Vitamins
2024, 16(22), 3879; doi: 10.3390/nu16223879
“Olive leaf extract supplementation improves postmenopausal signs: a randomized, double-blind, placebo-controlled parallel examine on postmenopausal girls.”
Authors: M. Imperatrice et al.
