A randomized, double-blind, placebo-controlled research printed within the journal Vitamins, assessed the consequences of omega-3 fish oil supplementation in sufferers with T2DM, discovering that omega-3 polyunsaturated fatty acids (PUFAs) could affect the construction and performance of intestine micro organism.
The authors from Nanjing, China, stated the outcomes “could have vital implications for intestine well being and systemic irritation, each of that are pivotal within the administration of diabetes”.
How would possibly omega-3 decrease sort 2 diabetes danger?
T2DM impacts over 90% of individuals with diabetes worldwide, with a projected prevalence of 12.2% (783.2 million individuals) by 2045.
PUFAs—together with α-linolenic acid, EPA and DHA—are recognized to profit a number of well being areas, and research have proven that omega-3 PUFAs could assist forestall T2DM by enhancing insulin signaling, decreasing irritation and influencing glucose metabolism.
Research additionally signifies that omega-3 PUFAs can positively impression intestine microbiota, which helps restore a balanced microbiome and improve anti-inflammatory compounds like short-chain fatty acids.
Imbalances within the intestine microbiome are linked to T2DM danger resulting from disrupted biochemical processes that result in insulin resistance. Subsequently, the researchers suggest {that a} wholesome intestine microbiome can help metabolic and immune operate, enhancing insulin sensitivity and blood glucose regulation.
Dysfunctional lipid metabolism can even play a job in T2DM, and studies have linked particular lipids, resembling lysophospholipids, triacylglycerols and poisonous 1-deoxyceramides with diabetes development.
Omega-3 PUFAs can alter the range and abundance of intestine microbiota. One study discovered that perilla oil wealthy in linolenic acid improved intestine well being in diabetic mice, and one other dietary survey discovered a major affiliation between the extent of whole omega-3 PUFAs and the alpha variety of the intestine microbiome.
Fish oil supplementation for sort 2 diabetes
Within the three-month research, the Chinese language researchers administered both a every day fish oil capsule or a placebo to 2 teams of 55 sufferers with T2DM.
Blood and fecal samples had been collected in the beginning and finish of the research to research serum lipids, glycemic parameters, intestine microbiota variety and lipidomics.
Findings indicated that fish oil-derived omega-3 PUFAs didn’t considerably scale back fasting plasma glucose ranges in comparison with baseline. Nonetheless, the fish oil group skilled vital reductions in serum fasting blood glucose, glycosylated hemoglobin, HOMA-IR, whole ldl cholesterol, triglycerides, LDL ldl cholesterol and non-HDL ranges in comparison with the placebo group after three months.
The intervention additionally altered glycerophospholipid metabolism and intestine microbiota composition. Particularly, the fish oil group confirmed a considerably decrease abundance of Desulfobacterota and lowered ranges of Colidextribacter, Ralstonia and Klebsiella in comparison with the placebo group.
On the similar time, ranges of Limosilactobacillus, Lactobacillus and Haemophilus considerably elevated. Related glycolipid metabolism indicators confirmed vital correlations with modifications in serum lipid metabolites and intestinal bacterial and fungal profiles.
“Sufferers with sort 2 diabetes could profit from fish oil supplementation,” the researchers concluded, including that “further validation via large-scale inhabitants trials is crucial”.
Supply: Vitamins 2024, 16(21), 3755
doi: 10.3390/nu16213755
“Enchancment in Glycolipid Metabolism Parameters After Supplementing Fish Oil-Derived Omega-3 Fatty Acids Is Related to Intestine Microbiota and Lipid Metabolites in Sort 2 Diabetes Mellitus.”
Authors: Xia, J. et al.
