Revealed in Ageing Analysis Opinions, the research reported that particular teams, similar to hypertensive people, could expertise decrease blood strain as a consequence of multivitamin and mineral (MVM) supplementation.
Undernourished aged and adults youthful than 65 years previous might also see a discount in infections with MVM use.
Nevertheless, MVM supplementation will not be related to a decreased danger of breast most cancers.
As such, researchers spotlight the necessity to establish people who would almost definitely profit from MVM supplementation.
“As this overview demonstrates, the proof for MVM supplementation to advertise wholesome longevity stays restricted and inconclusive,” they wrote. “
To reinforce the effectiveness of MVM supplementation in selling wholesome longevity, it’s important to establish people who’re almost definitely to learn from supplementation. Dietary wants differ significantly throughout people as a consequence of genetics, age, intercourse, well being standing and way of life.”
The research was performed by researchers from the Academy for Wholesome Longevity housed inside the Yong Lavatory Lin College of Drugs on the Nationwide College of Singapore (NUS).
Analysis funding got here from each NUS and Haleon, which is understood for its MVM manufacturers Centrum and Caltrate.
The speedy overview technique
The overview included 19 eligible meta-analyses assessing MVM use and bodily capabilities—cognitive well being, psychological well-being, immune response, blood strain regulation, COVID-19, being pregnant issues and start outcomes—with knowledge drawn from a complete of 5,535,426 members, together with pregnant ladies.
These meta-analyses included scientific trials, observational research and potential cohort research revealed on the MEDLINE and EMBASE databases from 2000 to 2025.
Usually, the scientific trials primarily assessed the impact of MVM on cognitive operate, psychological well-being, immune response, blood strain regulation and COVID-19 outcomes.
Cohort and case-control research, however, have contributed observational knowledge on most cancers incidence, cardiovascular occasions, being pregnant issues, start outcomes and pediatric situations.
Key findings
The researchers highlighted that the results of MVM supplementation on well being outcomes had been combined, with potential advantages primarily noticed in particular teams similar to older adults, people with decrease baseline dietary high quality and people with continual situations.
For instance, MVM supplementation was discovered to supply a small however vital discount in systolic blood strain however no vital discount in diastolic blood strain.
Subgroup analyses discovered larger reductions in blood strain ranges in hypertensive people and people with continual ailments, whereas minimal results had been reported in wholesome people with regular blood strain. MVM supplementation additionally didn’t decrease the chance of hypertension in people with regular blood strain.
“These RCT findings counsel that MVM consumption lowers blood strain in people with hypertension or continual illness however has little impact in normotensive people and doesn’t stop hypertension,” the researchers wrote.
One other instance is the potential of MVM supplementation to considerably scale back the variety of infections amongst adults below the age of 65.
In distinction, no vital impact of MVM supplementation on an infection charges in older adults, though findings indicated that MVM supplementation for at the least might scale back the variety of infections in undernourished older adults
“Total, RCT findings point out that MVM supplementation doesn’t scale back an infection danger in older adults from populations which can be a mixture of community-dwelling and institutionalized people who’re usually wholesome, however it might decrease an infection charges in youthful adults from populations which can be hospitalized, undernourished and acutely sick, notably burn sufferers,” the researchers wrote.
Results on ladies’s well being
There was additionally restricted proof on MVM’s advantages for ladies, together with pregnant ladies.
For instance, pooled evaluation of observational research didn’t discover associations between MVM use and incidence of breast most cancers.
“Thus, observational findings counsel that MVM supplementation will not be related to the chance of breast most cancers,” the researchers wrote.
Equally, there was an absence of advantages for pregnant ladies, together with a decrease danger of gestational hypertension or preeclampsia incidence, apart from one RCT involving 955 members that confirmed a possible protecting impact on gestational hypertension.
Future analysis
Primarily based on the findings, the researchers proposed that future scientific trials look at the results of MVM supplementation in particular populations which have demonstrated, or confirmed by way of laboratory checks, deficiencies in micronutrient ranges.
“Stratification by baseline dietary standing, dietary consumption and genetic or way of life elements could assist establish subgroups almost definitely to learn,” they wrote. “Total, the findings revealed an absence of consistency within the definition of MVM supplementation and substantial variability in MVM effectiveness relying on inhabitants, age, and well being standing.
“These outcomes highlighted the significance of shifting from generalized supplementation approaches to extra focused, personalised dietary methods to assist healthspan and longevity.”
Supply: Ageing Analysis Opinions, 2025. doi: 10.1016/j.arr.2025.102965. “Multivitamin and mineral use: A speedy overview of meta-analyses on well being outcomes”. Authors: Weilan Wang, et al.
