The examine, carried out by researchers on the Korea Institute of Instructional Facility Security and Nongshim Co., Ltd., enrolled 70 adults aged 20 to 59 and examined a branded ingredient, NS Collagen Peptide, at 1,650mg per day.
The product delivered 74.25mg of the purposeful dipeptide Gly-Professional inside that day by day dose.
The trial included wholesome women and men with out energetic pores and skin illness, latest dermatologic procedures, or systemic therapies which may confound outcomes. Ladies made up a lot of the cohort, which match the standard person profile for “magnificence from inside” merchandise.
Members took NS Collagen Peptide or a matched placebo for eight weeks, then entered a two-week washout.
Wrinkles improved early and stayed improved
Individuals who took collagen confirmed fewer wrinkles that saved enhancing over time. By day 10, wrinkles across the eyes (crow’s toes) have been shallower, and by week eight, they regarded even smoother. Two weeks after stopping, the pores and skin nonetheless regarded higher.
The traces across the mouth (nasolabial folds) additionally improved throughout supplementation. After stopping, the outcomes pale barely however nonetheless regarded higher within the intervention group than the placebo group.
On the neck, pores and skin saved enhancing and stayed agency even after the washout interval. Knowledgeable graders noticed the identical adjustments that imaging units measured: fewer and fewer deep wrinkles at week eight and two weeks later. The placebo group confirmed no actual change. This consistency between what consultants noticed and what the units measured exhibits that the adjustments have been actual and visual.
Pores and skin elasticity and firmness elevated
Collagen boosted the pores and skin’s means to stretch and bounce again. Key measures of elasticity (R2, R5, R7) elevated considerably by the fourth and eighth weeks, particularly on the cheeks, and stayed excessive even after stopping. For some measures, collagen customers pulled forward of placebo as early as day 10.
Within the “butterfly zone” on the cheeks — the place pores are dense — elasticity improved at each go to after baseline. In distinction, placebo customers misplaced elasticity after the washout interval.
Hydration rose on the floor and in deeper layers
Collagen customers confirmed higher hydration in each the outer and deeper pores and skin layers. Floor moisture rose by day 10 and saved climbing by weeks 4 and eight. Deep hydration adopted the identical development and stayed excessive after stopping.
Within the placebo group, deep hydration improved throughout dosing however dropped as soon as they stopped taking it, whereas floor moisture fell after washout. At each time level, collagen customers confirmed higher hydration than placebo customers.
This suits what folks generally find out about how collagen peptides work: as soon as absorbed, they’ll set off pores and skin cells (fibroblasts) to make extra collagen and hyaluronic acid, whereas slowing down the enzymes that break down the pores and skin matrix. These results assist the pores and skin maintain moisture and keep supple.
Denser dermis, decreased pores
Ultrasound scans confirmed that collagen customers constructed a denser dermis (the pores and skin’s deeper layer) by day 10, with regular good points by week eight and after washout. This meant a firmer, tighter look, according to fewer wrinkles and higher elasticity.
The placebo group, however, noticed non permanent good points that disappeared after stopping, particularly on the neck.
Collagen additionally diminished pore dimension and oiliness. Across the eyes, pore rely and quantity dropped by day 10, improved additional by week eight, and stayed low after washout.
Throughout the cheeks, folds and neck, collagen diminished the quantity, space and depth of pores, even when not each change reached statistical significance. These findings recommend collagen helped refine the pores and skin’s texture on the microscopic stage.
Sebum (oil) manufacturing additionally dropped on each cheeks by day 10 and stayed decrease by the washout interval. The placebo group confirmed solely a small, non permanent dip on one cheek.
This recommended a greater moisture-oil steadiness, which meant much less shine and smoother-looking pores and skin.
The collagen group additionally confirmed a gentle drop within the desquamation index — a measure of previous pores and skin cell buildup — on each the cheek and heel. This meant quicker turnover and a smoother, more healthy barrier, which remained even after stopping.
The placebo group, nevertheless, confirmed no actual change. The heel outcomes additionally recommended that collagen works all through the physique, not simply on the face.
What to check subsequent
Most individuals have been ladies, which match the audience however restricted how properly the outcomes utilized to males. The examine additionally didn’t embody blood or tissue biomarkers, so the researchers couldn’t immediately verify the organic mechanisms, although the outcomes match what previous analysis had proven.
In conclusion, the researchers wrote: “These findings assist the potential of collagen peptide NS as a protected and efficient purposeful meals ingredient with complete pores and skin well being advantages, notably in addressing cosmetically related issues comparable to wrinkle depth and pore visibility.”
Nonetheless, in addition they acknowledged: “Potential placebo results and seasonal adjustments weren’t mentioned. Moreover, whereas complete in endpoint scope, the examine didn’t incorporate invasive biomarker assessments.”
Supply: Nationwide Middle for Biotechnology Info. doi: 10.4014/jmb.2507.07008. “Pores and skin Anti-Getting older and Moisturizing Results of Low-Molecular-Weight Collagen Peptide Supplementation in Wholesome Adults: A Randomized, Double-Blind, Placebo-Managed Medical Trial”. Lee Eunkyoung, et al.
