Writing within the journal Medication, researchers from Liaoning College of Conventional Chinese language Medication and different establishments in China advised that the underlying mechanism could also be associated to the alleviation of oxidative stress and irritation.
“Rising proof means that focused dietary supplementation could mitigate oxidative stress by augmenting antioxidant protection mechanisms,” they wrote.
“Amongst dietary antioxidants, nutritional vitamins C and E have demonstrated explicit promise in attenuating oxidative injury by free radical scavenging and lipid peroxidation inhibition.”
Sanofi-Aventis Healthcare Pty Ltd, Australia supplied the nutritional vitamins used within the examine.
Focused diet for sarcopenia
Sarcopenia is the progressive lack of muscle mass and energy, primarily affecting older advert. It’s estimated to have an effect on roughly 10% of individuals over the age of 60.
The situation can result in a lowered high quality of life and independence, an elevated incidence of falls and a better threat of fractures.
Bodily exercise, significantly resistance coaching, is the first technique for stopping and managing sarcopenia. As well as, dietary interventions, reminiscent of rising protein consumption, are additionally advisable.
Oxidative stress performs a central position within the pathophysiology of sarcopenia. As folks age, lowered ranges of antioxidant enzymes in muscular tissues and insufficient micronutrient consumption within the weight loss program can contribute to elevated irritation. Moreover, whereas resistance coaching is useful, it could actually additionally generate reactive oxygen species, doubtlessly exacerbating oxidative stress if not correctly managed.
As antioxidants, nutritional vitamins C and E could assist to counteract oxidative stress. Nonetheless, the researchers famous that earlier research point out that supplementation can impede muscular diversifications relying on a person’s redox state.
“This dichotomy underscores the significance of precision diet methods, whereby antioxidant supplementation is tailor-made to deal with particular deficiencies, thereby optimizing train advantages,” they wrote.
Research particulars
The researchers randomly assigned sixty ladies between the ages of 60 and 75 with sarcopenia to devour both 1,000 mg of vitamin C and 335 mg of vitamin E or a placebo day by day for 12 weeks.
Contributors additionally attended three 50-minute coaching periods per week involving elastic band resistance workouts focusing on totally different elements of the physique.
Whereas each teams elevated their muscle mass, energy and bodily efficiency after 12 weeks, individuals within the antioxidant group had bigger will increase in arm lean mass, skeletal muscle mass index, handgrip energy and knee extension energy.
The researchers didn’t observe a big distinction in bodily efficiency between the 2 teams.
The findings indicated that serum vitamin C and E ranges on the finish of the examine had been satisfactory within the complement group however not within the placebo group. As well as, “adjustments in blood biomarkers proved the useful results of nutritional vitamins C and E supplementation on physiological adaptation to RT [resistance training],” the researchers wrote.
They reported that lowered glutathione (GSH) and the lowered glutathione/oxidized glutathione (GSH/GSSG) ratio elevated within the complement group, which they famous could also be attributed to the synergistic results of the nutritional vitamins selling GSH synthesis, regeneration and lowered consumption.
“Elevated serum GSH ranges are significantly vital, as skeletal muscular tissues can ship GSH to the circulation, and elevated serum GSH displays constructive muscle diversifications to train coaching,” the researchers wrote.
Additionally they discovered considerably decrease ranges of IL-6, main them to hypothesize that the nutritional vitamins improved the redox state or exerted anti-inflammatory results.
“It has been reported that lowered circulating ranges of IL-6 play an necessary position in mitigating muscle mass and energy loss in sarcopenia,” they wrote.
The examine advisable future analysis to discover whether or not longer-term interventions might result in additional enhancements in bodily efficiency.
Supply: Medication 104(34) p. e43976, Aug. 22, 2025. | doi: 10.1097/MD.0000000000043976 “Results of nutritional vitamins C and E supplementation mixed with 12-week resistance coaching in older ladies with sarcopenia: A randomized, double-blind, placebo-controlled trial.” Authors: X. Liu et al.
