Printed within the journal Antioxidants, the analysis evaluated the consequences of a DHA-enriched practical beverage containing soy protein, tuna oil, sunflower seed oil, floor black sesame and a vitamin B advanced on the rising hyperlink between mobile senescence and menopause-related cognitive decline.
“Our outcomes counsel the potential of a practical beverage containing DHA-enriched tuna oil with respect to enhancing the cognition of perimenopausal and postmenopausal girls,” they reported. “The mechanism accountable might depend upon the dose of the practical beverage.”
Thai Union Group Public Firm Restricted provided the check product used within the examine, which was funded by the Thai Program Administration Unit for Competitiveness.
Omega-3s and mobile growing older
Mobile senescence, the mobile response to emphasize leading to everlasting cell cycle arrest, will be triggered by each exterior elements like oxidative stress and inside elements equivalent to mitochondrial dysfunction and telomere shortening.
As individuals age, senescent cells accumulate, resulting in declines in physiological features. Senescent cells within the mind or supporting tissues might contribute to neuroinflammation and neurodegenerative diseases. Senescence also can have an effect on hormone ranges, gamete high quality and tissue operate in reproductive organs, and almost 50% of women over 40 experience reproductive aging.
Telomere shortening, mitochondrial dysfunction and reduced sirtuin-1 (SIRT1) exercise contribute to systemic growing older, together with reproductive growing older. These elements can impair the amount and high quality of oocytes, the immature egg cells present in feminine ovaries, resulting in menopause, which by means of estrogen decline, impacts mind well being and cognition.
Research has proven that omega-3 polyunsaturated fatty acids (PUFAs) can shield neurons, enhance cognitive capacity and forestall neurodegeneration, and previous clinical trials have discovered that long-chain omega-3 fatty acids (LC-n3-FA) might enhance reminiscence recall in adults over 50 and that six months of each day DHA might improve working reminiscence in adults ages 18 to 45.
In their very own work, the Khon Kaen College analysis group previously reported that omega-3-rich tuna oil decreased oxidative stress and irritation, strengthened cholinergic features and improved reminiscence in a menopausal animal mannequin.
Research particulars
This newest randomized, double-blind, placebo-controlled parallel examine randomly assigned 60 feminine perimenopausal and postmenopausal members (ages 45 to 60) to obtain both a placebo, a low dose (2,600 mg/day) or a excessive dose (6,000 mg/day) of the complement for eight weeks.
They assessed mind waves, working reminiscence and blood serum ranges, together with the density of Lactobacillus and Bifidobacterium spp. in feces earlier than consumption and at four-week intervals. In addition they measured telomere size and ranges of whole phenolic compounds and DHA in the beginning and finish of the examine interval.
Findings indicated that consuming the tuna-oil-containing practical beverage for eight weeks at each doses will increase N100 amplitude, the brainwaves related to early sensory processing, enhancing easy response instances and spatial reminiscence. Nevertheless, solely the upper dose improved phrase recognition efficiency and P300 amplitude, which is related to consideration and dealing reminiscence.
Topics consuming the upper dose additionally confirmed reductions in enzymes concerned in neurotransmitter degradation, AChE and MAO, in addition to MDA, an indicator of oxidative stress. Professional-inflammatory cytokines TNF-α and IL-6, markers of irritation, had been decreased, and GPx exercise, the antioxidant enzyme, was elevated. Individuals within the larger dose group additionally confirmed elevated serum DHA ranges.
Apparently, solely the low-dose group displayed improved telomere size and elevated SIRT1 ranges, a protein related to growing older, metabolism and mobile restore. As attainable rationalization, the researchers famous that “the DHA/EPA ratio is appropriate for this dose, as noticed with respect to the modifications noticed in telomere assessments.”
No important modifications in Lactobacillus and Bifidobacterium spp. ranges had been noticed in both group following supplementation.
The researchers concluded {that a} excessive dose of the practical beverage improved cognitive operate, consideration and dealing reminiscence, doubtless stemming from decreased oxidative stress and irritation and enhanced neurotransmission in consideration and cognition circuits, which was additionally maybe improved by DHA concentrations. The low-dose beverage additionally boosted consideration and dealing reminiscence.
The examine urged that future analysis deal with present limitations by increasing the pattern measurement and incorporating a broader vary of oxidative stress markers.
As a result of relying solely on MDA parameter might not present a complete illustration of oxidative stress, it additionally known as for future research to incorporate further biomarkers equivalent to F2-isoprostanes, protein-bound 4-hydroxynonenal, and 8-hydroxy-2′-deoxyguanosine, which might mirror oxidative harm throughout lipids, proteins and DNA.
‘Ageless’ Consumption
For a deeper understanding of ageless consumption and its influence on product growth, join us in Vienna from 23–25 June at the NutraIngredients Active Nutrition Summit 2025 to discover how manufacturers are supporting energetic life throughout each era.
Supply: Antioxidants 2025, 14(5), 520. doi: 10.3390/antiox14050520. “A Randomized, Double-Blind, Placebo-Managed, Parallel-Group, 8-Week Pilot Research of Tuna-Byproduct-Derived Novel Dietary supplements for Managing Mobile Senescence and Cognitive Decline in Perimenopausal and Postmenopausal Ladies”. Authors: Wattanathorn, J et al.
