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Short-term supplementation of collagen hydrolysate or dairy protein does not enhance recovery from exercise-induced muscle damage, revealed an RCT.

admin by admin
January 25, 2025
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Short-term supplementation of collagen hydrolysate or dairy protein does not enhance recovery from exercise-induced muscle damage, revealed an RCT.



Neither collagen hydrolysate nor dairy protein improved exercise-induced muscle injury higher than the placebo, in line with researchers from Massey College, New Zealand.

“Our findings counsel that, when consumed for 3 days after damaging train, collagen hydrolysate or dairy protein doesn’t expedite the speed of restoration any higher than an isoenergetic placebo.

“Our findings add to the rising proof that means that dairy protein has little profit for restoration from exercise-induced muscle injury,” wrote researchers in Vitamins.

Moreover, they added that for collagen hydrolysate to enhance restoration, supplementation for prolonged intervals of time could also be obligatory: “For collagen hydrolysate to have a useful impact on how muscle responds to eccentric train, consuming collagen hydrolysate for a chronic interval, of no less than 9 days, previous to train could also be obligatory.”

Managing exercise-induced injury

Train-induced muscle injury is brought on by train that’s strenuous, repetitive, novel, and/or includes eccentric muscle contractions, similar to downhill operating.

While that is momentary, and could also be useful for future muscle adaptation, it may possibly create issues for normal exercisers by impairing efficiency throughout subsequent bouts of train or by inflicting a disruption to regular every day actions that aren’t in any other case a problem.

Dairy protein supplementation, which incorporates whey, casein, and complete milk, was thought to be essentially the most prescribed answer for this concern, amongst different interventions that included omega-3 fatty acids, varied amino acids, polyphenols, and natural extracts.

Regardless of combined proof for its results on exercise-induced muscle injury, and a big environmental footprint, dairy protein’s comfort and results on muscle protein synthesis make it the foremost contributor to a protein complement business that’s anticipated to be price over USD 10 billion by 2030 within the US alone, in line with researchers.

Researchers and the complement business are due to this fact exploring new protein sources like bovine collagen, a by-product of the meat business wealthy in amino acids that help collagen synthesis and tissue restore. Collagen hydrolysates break down into amino acids and peptides, similar to hydroxyprolylglycine (Hyp-Gly) and prolylhydroxyproline (Professional-Hyp), that are absorbed into the bloodstream and assist in muscle restoration.

On this research, researchers aimed to evaluating the consequences of collagen hydrolysate and dairy protein on restoration from eccentric train.

A double-blind, placebo-controlled research

Thirty-three lively, wholesome males aged between 18 and 40 years participated on this research. All members carried out cardio and resistance train no less than twice per week within the six months previous to this research and had honest to good cardio health.

The research used a double-blind, placebo-controlled design to check the consequences of collagen hydrolysate, dairy protein, and a placebo on restoration from half-hour of downhill operating.

Members have been grouped based mostly on their VO2max, a measure of the utmost quantity of oxygen the physique can use throughout intense train, which displays health ranges.

They have been then randomly assigned to one of many three teams – collagen hydrolysate (CH), dairy protein (DP), and placebo (PLA). No variations in imply age, peak, physique mass, cardio health (VO2max), downhill operating pace, and power and protein consumption between therapy teams have been discovered.

To standardise power consumption, members got a drink containing maltodextrin – offering 1000 kJ of power – two hours earlier than their trial to match the power content material of the dietary supplements used later.

After no less than one week, members returned for the principle trial. Baseline measures of exercise-induced muscle injury – together with blood sampling, muscle soreness, muscle operate, and operating effectivity – have been taken.

They then accomplished half-hour of downhill operating at 80% of their VO2max pace. After a 30-minute relaxation, the identical measures have been repeated, and members consumed their first complement (collagen hydrolysate, dairy protein, or placebo).

For the following three follow-up periods – 24, 48, and 72 hours after the run – members consumed their assigned complement two hours earlier than returning to the lab for assessments.

The complement powders – collagen hydrolysate, dairy protein, and placebo – have been sealed in foil packaging and labelled A, B, or C by employees uninvolved within the research.

The collagen hydrolysate complement was a spray-dried prototype comprised of dehaired cowhide sourced and processed inside New Zealand. The dairy protein complement integrated milk protein focus 470 from Fonterra Cooperative Group Ltd, combining whey and casein for his or her quick and sustained protein launch results. The placebo contained maltodextrin supplied by Archer Daniels Midland Firm.

To make sure consistency, all dietary supplements have been designed to have the identical power content material, with the collagen and dairy protein powders every offering 25 g of protein. They have been all flavoured with pure and synthetic vanilla to make sure consistency. Every dose was combined with 250 mL of water in a shaker earlier than consumption.

The outcomes

The downhill operating brought on important exercise-induced muscle injury, evident from will increase in muscle soreness, declines in bounce peak, power, and operating effectivity, and elevated biomarkers of muscle injury (creatine kinase) and irritation (interleukin-6 and C-reactive protein).

Nevertheless, no important variations have been noticed between the collagen, dairy protein, or placebo teams for any of those measures.

For instance, countermovement bounce peak decreased considerably, with a discount from ~38 cm pre-exercise to ~35 cm at half-hour, persisting beneath baseline for as much as 72 hours.

Working effectivity, as measured by VO2, worsened considerably, rising from ~42 mL/kg/min pre-exercise to ~45 mL/kg/min instantly post-run and remaining elevated for 48 hours.

Collagen hydrolysate was not equal, nor extra useful than dairy protein, and neither protein supply was higher than the placebo, noticed researchers.

“These findings counsel that the post-exercise consumption of CH or DP doesn’t enhance indices of exercise-induced muscle injury throughout the acute restoration interval in recreationally lively males,” mentioned researchers.

Opposite to expectations, neither collagen hydrolysate nor dairy protein outperformed PLA in enhancing muscle operate, soreness, or inflammatory markers. Though collagen hydrolysate has proven advantages in some research, notably for countermovement bounce efficiency, findings stay inconsistent as a result of various methodologies, supplementation timing, and participant components. The dearth of a transparent profit on this research means that collagen hydrolysate or dairy protein supplementation post-exercise could also be inadequate for restoration, and long-term or pre-exercise supplementation is perhaps obligatory for protecting results. Additional analysis is required to make clear their roles in mitigating exercise-induced muscle injury.

“We suggest that people particularly wanting to hurry up restoration after strenuous, damaging train ought to not take into account acute, post-exercise protein supplementation as a dependable and precious technique,” concluded researchers.

Supply: Vitamins

DOI: https://doi.org/10.3390/nu16244389

“Evaluating the Results of Collagen Hydrolysate and Dairy Protein on Restoration from Eccentric Train: A Double Blind, Placebo-Managed Examine”

Authors: Rachel Barclay, Jane Coad et al.



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Tags: CollagenDairyDamageEnhanceexerciseinducedhydrolysateMuscleProteinRCTRecoveryRevealedShorttermSupplementation
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