Writing within the Journal of Microbiology and Biotechnology, researchers from Seoul-based Kookmin College and Kookmin Bio reported that KLP-KM2, a postbiotic formulation of Lactiplantibacillus plantarum KM2 derived from aged beef, could “improve power metabolism and mobility in older adults.”
L. plantarum is a well-studied probiotic that has gained consideration for its advantages for exercise performance, https://www.nutraingredients.com/Article/2024/04/18/Lactiplantibacillus-probiotic-may-support-weight-management-Study/, constipation and alleviating symptoms in specific medical conditions.
Nevertheless, dwell micro organism could pose a danger to some individuals, reminiscent of older adults and people with compromised immune methods, and researchers are eager to determine protected alternate options reminiscent of postbiotics.
The present examine used L. plantarum to supply the postbiotic KLP-KM2 and located that 12 weeks of supplementation promoted the prevalence of the Veillonella species of micro organism.
This species has beforehand been linked to muscle and power advantages resulting from its short-chain fatty acids (SCFAs) manufacturing.
Advantages of postbiotics
The International Scientific Association for Probiotics and Prebiotics (ISAPP) defines a postbiotic as a “preparation of inanimate microorganisms and/or their elements that confers a well being profit on the host.”
Postbiotics are inactivated microbial cells with or with out metabolites that contribute to demonstrated well being advantages. They are often administered to the intestine, mouth, pores and skin, nostril or urogenital tract to modulate the immune system, improve epithelial obstacles, assist the intestine and synergize with indigenous microbiota.
The present examine famous that postbiotics don’t carry the potential danger of infections reminiscent of sepsis and bacteremia, which some studies present is extra prevalent in individuals taking probiotics, though it’s nonetheless rare.
Postbiotics can also be preferential for older adults whose immune perform has declined resulting from immunosenescence, which is modifications in cell perform brought on by getting old.
Examine particulars
The randomized, double-blind, placebo-controlled examine evaluated a postbiotic consisting of a heat-treated L. plantarum KM2 fermentation advanced, KLP-KM2. Eighty members age 50 and above took 9 g of both KLP-KM2 or placebo, divided into two doses per day, for 12 weeks.
Some topics had been excluded for causes reminiscent of drugs and withdrawal of consent, leading to 66 members. Researchers used stool samples, metagenomic sequencing, self-reports and scientific assessments to guage the consequences of the postbiotic and any antagonistic occasions.
Evaluation of antagonistic occasions and monocyte ranges within the preliminary 80 members indicated that KLP-KM2 is protected for human use.
They discovered that the Veillonella species was extra prevalent within the KLP-KM2 group, suggesting the lactate within the postbiotic could also be accountable, as Veillonella ferments lactate to transform into SCFAs reminiscent of acetate and propionate.
The examine famous that the Veillonella species promote intestine well being and are continuously detected within the microbiome of athletes. Its capacity to ferment lactate is related to enhancements in train efficiency and muscle fatigue, and former research have urged it could ameliorate muscle losing.
“The convergence of those documented therapeutic properties with the KLP-KM2-mediated alterations in intestine microbiota composition noticed in our human trial suggests vital potential for KLP-KM2 as a protected postbiotic intervention within the administration of sarcopenia, characterised by age-associated decline in muscle mass, energy and performance,” the researchers wrote.
They known as for additional research that present insights into the metabolic pathways related to KLP-KM2’s advantages.
IPA World Congress Probiota 2025
Postbiotics is without doubt one of the key themes for the upcoming IPA World Congress + Probiota 2025, which is able to happen in Copenhagen, Feb. 5 to 7.
The Postbiotics session will function shows from Professor Simone Guglielmetti from the College of Milano-Bicocca and Professor Maria Rescigno from Humanitas College. Professors Guglielmetti and Rescigno will then be a part of a panel dialogue that additionally options ADM’s Dr. Richard Day, Probiotical’s Marco Pane and BioGrowing’s Hongwei Wang.
Different key periods will cowl longevity and healthspan, the pantryome, bioinformatics, the gut-brain axis, next-gen probiotics, microbiome modulation for athletic efficiency, the state of the market and way more!
For extra data and to register, please click on HERE
Supply: Journal of Microbiology and Biotechnology 2025. 35: e2411069
“Analysis of the Security and Impression of Warmth-Handled Lactiplantibacillus plantarum KM2 Fermentation on Intestine Microbiome Structure”
Authors: S. Received et al.
