The examine, revealed within the journal Nutraceuticals, highlights the potential of liposomal expertise to beat vitamin C absorption challenges and suggests standalone advantages of the liposomal materials itself.
“The outcomes recommend that LEC [Liposomal vitamin C] supplies antioxidant and immune advantages above AA [ascorbic acid], helpful in preventive drugs,” wrote researchers from NIS Labs in Canada and the USA.
Liposomal expertise
Liposomal expertise has gained consideration as an efficient innovation in delivery systems to improve bioavailability.
Liposomes are tiny, spherical vesicles comprised of lipid bilayers much like cell membranes. Due to their construction, they make excellent provider programs for medicine and nutraceuticals, capable of merge with the cell and ship their contents.
As such, liposomal-based drug supply programs are approved to treat diseases equivalent to most cancers and infections, and substances producers are marketing them to offer formulators enhanced efficacy and absorption.
Within the present examine, the researchers spotlight the challenges of absorbing vitamin C as a result of its solubility in water and the transport programs it depends on to soak up it from the intestine.
“Vitamin C uptake requires transport throughout the intestine epithelium to get into the blood circulation, and to cross cell membranes to get into cells in our physique,” Dr. Gitte Jensen, founder and analysis director, NIS Labs, informed Nutraingredients.
“Our scientific trial confirmed that this limitation might be bypassed when the vitamin is encapsulated into liposomal nanoparticles, the place the vitamin is wrapped in helpful phospholipids, equivalent to phosphatidylcholine, an important part of our cell membranes.”
Implications for well being
The examine notes that vitamin C’s antioxidant properties have been linked to neuroprotection, cognitive assist, and mind well being. As a co-factor for collagen, vitamin C advantages tissue integrity, wound therapeutic, and wholesome getting older.
Moreover, it acts as an epigenetic regulator influencing the immune system via kinase activation.
“We demonstrated fast enhancements in antioxidant standing and immune system preparedness for pathogenic challenges, which means that consuming liposome-encapsulated vitamin C is effective each in preventive well being and through well being challenges which are related to oxidative stress,” commented Dr. Jensen.
Research particulars
The double-blinded, placebo-controlled cross-over examine in contrast LEC to a few controls: ascorbic acid (AA), the phospholipid fraction composing the liposome, and placebo. The purpose was to judge LEC’s uptake, antioxidant, and immune-modulating results.
The LEC makes use of the patented Lypo-Spheric expertise marketed by LivOn Labs within the USA underneath the model Altrient. The corporate additionally provided the opposite check merchandise and sponsored the examine.
The researchers randomized twelve wholesome contributors to eat 1g of one of many 4 dietary supplements at 4 separate clinic visits spaced one week aside. On the finish of the examine interval every participant had taken all 4 complement choices in numerous sequences.
Blood samples had been taken at baseline and two, 4, and 6 hours after the check merchandise or placebo, and the researchers evaluated the results of the interventions utilizing applicable strategies.
They discovered that each LEC and AA considerably elevated blood plasma ranges of vitamin C in any respect time factors, however the LEC improve was 55% greater than that of AA on the two-hour time level.
Ferric-reducing antioxidant energy (FRAP) at 2 hours was 3.6% for AA and 9% for LEC, so nearly 3 instances greater for LEC.
Mobile Antioxidant Safety (CAP-e) at 4 hours was 5.6% for AA and 10.5% for LEC, so nearly 2 instances greater for LEC.
When analyzing the DNA/RNA oxidation at 2 hours, the outcomes confirmed an 11% discount after consuming the phospholipids.
“The blood checks we used included vitamin C ranges in addition to antioxidant safety in numerous assays, together with NIS Labs’ patented methodology for mobile antioxidant safety (CAP-e). The phospholipids alone had vital anti-inflammatory results inside 2-6 hours, displaying that the liposomal materials has its personal well being advantages,” stated Dr. Jensen.
Supply: Nutraceuticals
2024, 4(4), 626-642; doi: 10.3390/nutraceuticals4040034
“Enhanced bioavailability and immune advantages of liposome-encapsulated vitamin C: a mix of the results of ascorbic acid and phospholipid membranes.”
Authors: S.V. McGarry et al.
