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The researchers in Poland examined the probiotic mix in a randomized, double-blind, multicenter, placebo-controlled research over 12 months, with the authors discovering that it could provide a viable technique for bettering bone well being post-menopause.
Probiotics for postmenopausal bone well being
Postmenopausal girls face important dangers to bone well being because of declining estrogen ranges, resulting in gradual bone loss and heightened threat of osteopenia and osteoporosis—situations marked by low BMD and better fracture susceptibility.
The intestine microbiota performs important roles in well being, together with immune operate, intestine barrier integrity, and nutrient absorption, together with minerals important for bone metabolism.
Intestine micro organism may boost calcium absorption by means of short-chain fatty acids (SCFAs) produced by bacterial fermentation. Moreover, dysbiosis can disrupt bone remodeling, doubtlessly impacting bone well being.
Given the intestine microbiota’s function in bone well being, researchers are exploring how modifying its composition would possibly assist forestall osteopenia and osteoporosis.
A current meta-analysis of preclinical research means that probiotics, particularly lactobacilli species, could forestall postmenopausal osteoporosis. Nevertheless, medical trials in postmenopausal girls haven’t but confirmed enhancements in bone mineralization.
“Analysis targeted on postmenopausal girls is a precedence for Nordic Biotic due to the distinctive challenges they face with bone well being and metabolic adjustments,” Michał Jakubowski, CEO of Nordic Biotic instructed NutraIngredients.
“By specializing in postmenopausal girls, we are contributing to a vital side of ladies’s well being.”
The gut-bone axis
In accordance with Jakubowski, the intestine–bone axis presents a possibility to develop dietary supplements that help each intestine well being and bone density, offering a holistic method to lowering osteoporosis threat in postmenopausal girls.
“To leverage this axis successfully, the trade can concentrate on combining probiotic strains with vitamins like calcium, vitamin D, and vitamin K2, that are crucial for bone well being,” he instructed NutraIngredients.
“Probiotics that improve nutrient absorption and cut back irritation might considerably increase the efficacy of those bone-supporting vitamins, providing a extra complete method to supplementation.”
He defined that deciding on strains that increase calcium and magnesium absorption and enhance SCFA manufacturing permits the creation of formulations that help optimum mineral uptake.
Moreover, focusing on intestine irritation could assist defend bone well being by decreasing bone loss because of irritation.
As Professor Bożena Cukrowska, CSO at Nordic Biotic defined, the intestine–bone axis continues to be rising as an space of analysis, subsequently mechanisms are but to be absolutely understood.
“Whereas current research have highlighted the connection between intestine microbiota and bone metabolism, the precise pathways, notably in relation to probiotics’ affect, are under-researched,” he mentioned.
“Nevertheless, it’s identified that particular probiotic strains, akin to LP140 are in a position to produce neurotransmitters (e.g. GABA) affecting the mind’s capabilities. As extra proof emerges, this space holds potential for novel therapeutic approaches for bone well being upkeep.”
Probiotics could cut back bone loss in postmenopausal girls
The researchers recruited 167 early postmenopausal girls to took both a mixture of L. paracasei LPC100 (DSM 33793) and L. plantarum LP140 (DSM 33804), or placebo.
Outcomes confirmed that girls within the placebo group had a big drop in lumbar T-scores, obtained by means of dual-energy X-ray absorptiometry (DXA) scans, whereas the probiotic group confirmed a smaller, statistically insignificant discount.
The probiotic group additionally confirmed much less vitamin D depletion, suggesting a protecting impact, although no main variations between teams had been seen.
By way of gastrointestinal well being, the probiotic group reported delicate enhancements in signs like belly ache and flatulence.
“SCFAs, akin to these produced by Lactobacillus paracasei LPC100 and Lactobacillus plantarum LP140, play a vital function in enhancing mineral absorption and sustaining bone mineral density (BMD),” defined Cukrowska.
“They assist to create a extra acidic setting within the colon, facilitating calcium solubility and absorption.
“Moreover, LPC100 and LP140 could activate different metabolic pathways, just like the manufacturing of bioactive peptides, that might additional affect bone resorption and formation steadiness.”
The researchers concluded that L. paracasei LPC100 and L. plantarum LP140 could assist forestall bone mineral loss and vitamin D deficiency in postmenopausal girls.
They recommend that future analysis ought to assess bone turnover biomarkers and intestine microbiome.
Supply: J. Clin. Med. 2024, 13(19), 5977; https://doi.org/10.3390/jcm13195977
“The Impact of Lacticaseibacillus paracasei LPC100 and Lactiplantibacillus plantarum LP140 on Bone Mineral Density in Postmenopausal Girls: A Multicenter, Randomized, Placebo-Managed Examine”
Authors: Głogowska-Szeląg, J. et al.
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