Revealed within the journal Vitamins, the pilot examine instructed that consuming 500 mg every of resveratrol and vitamin C day by day ameliorates oxidative stress, a key driver for post-menopausal metabolic illnesses.
Nonetheless, throughout the three-month intervention, the complement didn’t present important variations in scientific and biochemical markers for insulin resistance, prompting requires additional research.
The researchers in Mexico famous an absence of research that present true statistical significance with synergistic antioxidant mixtures akin to resveratrol and vitamin C.
“It’s the first pilot examine that evaluates the mix of two antioxidants and its impact on oxidative stress and insulin resistance,” they wrote.
Antioxidants and menopause
Adjustments in hormones throughout menopause can enhance the danger of metabolic illnesses akin to insulin resistance, highlighting an elevated want for antioxidants.
In 2020, the researchers on the present examine reported that postmenopausal Mexican ladies current larger concentrations of oxidative stress markers than ladies of reproductive age. They proposed that this is because of getting old, weight problems, decrease estrogen and food regimen.
They defined that estrogen produces direct antioxidant results by rising the actions of antioxidant enzymes and defending cells from free radical injury to the mitochondrial DNA.
Falling estrogen ranges in menopause change the lipid profile and enhance lipoperoxidation. If the food regimen in menopause is depleted of antioxidant nutritional vitamins and phytonutrients, oxidative stress might enhance.
Different analysis signifies that declining estrogen places postmenopausal ladies susceptible to insulin resistance and cardiovascular disease. Oxidative stress is the important thing mechanism concerned.
Research particulars
The examine recruited 46 ladies between the ages of fifty and 60 identified with early post-menopause and presenting with insulin resistance. The members weren’t taking hormone alternative remedy.
Individuals have been blindly randomized into one in every of three teams: 500 mg resveratrol, 500 mg vitamin C, or 500 mg of every collectively. All teams obtained two capsules, with a placebo changing the opposite complement within the single-dose teams.
The examine famous that antioxidants can turn out to be oxidants when current in excessive concentrations, and subsequently administering them in pairs might keep away from the technology of latest free radicals that act as pro-oxidants.
The researchers evaluated blood samples, scientific standing and antioxidants earlier than and after the three-month intervention interval.
The resveratrol and vitamin C group confirmed a major 33% lower in lipoperoxidation. This was in comparison with a 25% and 15% lower in resveratrol and vitamin C, respectively, which didn’t attain statistical significance because of the small pattern measurement.
Moreover, the examine reported a major 39% lower in oxidative injury to proteins with the mix complement.
The full antioxidant enhance was 30% within the mixture group, 28% within the vitamin C group and 11% within the resveratrol group.
There have been nonetheless no important variations between the beginning and endpoint values for weight, BMI, glucose, insulin, lipid profile and uric acid in any of the teams.
The researchers famous examine limitations together with the shortage of a management group and the restricted range of the members, recommending that findings be interpreted with warning and that future research embrace bigger pattern sizes.
Supply: Vitamins 2024, 16(21), 3775
doi: 10.3390/nu16213775
“The administration of resveratrol and vitamin C reduces oxidative stress in postmenopausal ladies—a pilot randomized scientific trial.”
Authors: A. Montoya-Estrada et al.
