The human randomized management trial, revealed within the journal Vitamins, confirmed that after taking 20g of a technologically modified collagen complement each day for 3 months, members with obese or weight problems decreased their weight and physique mass index (BMI) and had fewer emotions of starvation.
The complement had further optimistic results on waist measurement, systolic blood strain, fatty liver index, and fat-free mass.
As a hypocaloric weight-reduction plan didn’t accompany the examine, the researchers hypothesize that the complement’s swelling capability induced fullness when taken with water, affecting appetite-regulating hormones and sensations of starvation.
Urge for food-regulating dietary supplements
Dietary supplements that induce satiety have the potential to regulate starvation and overconsuming energy in people who’re obese or thought of overweight.
Research have proven that changed gels from plant sources reminiscent of RPG dietary fiber, cellulose, and deacetylated konjac glucomannan can improve satiety and assist in weight administration. These compounds can take up water and develop their quantity, which means that individuals really feel fuller after they eat them.
The authors of the present examine notice that few research have assessed compounds of animal origin, reminiscent of collagen, for this objective.
Bovine collagen consists of very lengthy amino acid chains, which make it helpful for numerous features in meals expertise. When the construction of collagen is modified, water could be integrated into the proteins, rising their quantity and mass.
Research particulars
The researchers carried out an in vitro examine, human trial, and animal examine.
Firstly, they examined the collagen’s digestibility in vitro and located that it confirmed low digestibility (lower than 60%) and excessive swelling capability (greater than 1900%).
Within the human trial, 64 obese or overweight adults have been randomized into an experimental or management group for the 12-week examine interval, and each acquired wholesome dietary suggestions.
The management group took a protein bar enriched with bovine collagen and 250 ml water 45 minutes earlier than lunch and 45 minutes earlier than dinner, and the experimental group took solely the water. The power worth for every bar was 90 kcal, and the entire collagen in each bars was 20g.
After three months, the collagen group considerably decreased their weight, physique mass index (BMI), waist circumference, systolic blood strain, and fatty liver index and elevated their fat-free mass in comparison with the management group.
They reported feeling fuller after the complement with fewer emotions of starvation, and the degrees of the hormone leptin, which regulates urge for food, had decreased. Additionally they observed extra emotions of thirst, though this was not important in comparison with the management group.
The researchers additionally noticed decreased ranges of the hormone ghrelin, which will increase urge for food, in rats given the complement.
“These information counsel that taking 10 grams of this collagen earlier than lunch and dinner ought to enhance adhering to a dietary routine or cut back snacks between meals,” researcher Fermín Ignacio Milagro instructed NutraIngredients.
As a result of the examine didn’t measure the members’ dietary consumption, the researchers notice that they will’t be sure that the collagen complement diminished the caloric consumption or if there are different mechanisms at play. They suggest that additional analysis be carried out to make clear this.
“A brand new intervention examine in a inhabitants with increased ranges of fasting glucose, whole ldl cholesterol, blood strain or transaminases, and controlling meals consumption may assist to make clear the mechanism of motion and the potential further advantages of this technologically modified collagen,” Milagro stated.
“A postprandial evaluation of gastrointestinal peptides – acyl-ghrelin, CCK, GLP-1, and PYY – may additionally assist to discern the impact on satiation.”
Supply: Vitamins 2024, 16(20), 3550; https://doi.org/10.3390/nu16203550
“Anti-obesity results of a collagen with low digestibility and excessive swelling capability: a human randomized management trial.”
Authors: M. Lopez-Yoldi at al.
