The examine, revealed in Intestine Microbes, is reportedly the primary large-scale built-in metagenomic cohort examine of the microbiomes of long-lived individuals.
Researchers from Solar Yat-sen College and the Heart of Human Microecology Engineering and Know-how of Guangdong Province additionally used a statistical evaluation approach referred to as Mendelian randomization (MR) to deduce the potential causal relationship between longevity and intestine microbiome.
“The primary notable discovering of our examine is that when combining knowledge from eight longevity cohorts, the alpha-diversity of intestine microbiota in long-lived populations was noticed to be greater in comparison with that in youthful populations,” they wrote.
“… a various intestine microbiota ecosystem might recommend versatile adaptability to perturbations, resembling sickness, and will doubtlessly function a marker of longevity,” they added.
Centenarian microbiota
The examine provides to a small however rising physique of science exploring how the microbiota and microbiome of long-lived people might maintain some key to wholesome getting old and longevity.
As reported in 2021 by NutraIngredients-USA, a definite set of intestine microbes in centenarians might contribute to longevity.
The brand new examine expands the proof on this rising space, with evaluation of 1,156 fecal samples revealing that many bacterial species resembling Limosilactobacillus fermentum, Christensenellaceae bacterium NSJ-44 and Neglecta timonensis are particularly prevalent within the guts of extraordinarily aged individuals, in comparison with youthful individuals.
“A few of these species could also be related to longevity or particular to getting old,” the researchers wrote.
Moreover, individuals over the age of 90 (together with centenarians) have been discovered to have constantly greater ranges of Eisenbergiella tayi, Methanobrevibacter smithii, Hungatella hathewayi, Ruthenibacterium lactatiformans and Enterocloster lavalensis.
Commenting on particular practical pathways linked to those species, the researchers famous that each one are linked to processes related to physiological processes throughout getting old. For instance, E. tayi might contribute to bacterial protein N-glycosylation linked to the “folding, high quality management, stability, transport and performance of proteins”, they famous.
As well as, M. smithii and D. fairfieldensis are concerned in a number of completely different processes which can be linked to getting old, together with the manufacturing of metabolites resembling coenzyme Q10 and vitamin K2.
The information additionally confirmed that Alistipes and Akkermansia muciniphila have been enriched within the intestine microbiota of the three largest cohorts of long-lived people, and “MR evaluation additionally suggests their potential causal relationships with longevity.”
Mining for novel probiotics
Different analysis teams all over the world have already begun to discover if the microbiomes of centenarians could possibly be mined for novel probiotic strains to help healthspan in different people.
Certainly, a 2021 paper in Frontiers in Immunology reported that the mixture of centenarian-derived Limosilactobacillus fermentum SX-0718, Lacticaseibacillus casei SX-1107, Bifidobacterium longum SX-1326 and B. animalis SX-0582 might exhibit anti-aging potential and defend in opposition to neuro-inflammation by way of the microbiota-gut-brain axis.
When administered to lab mice, the probiotic mixture was additionally related to a rise within the expression of molecules that enhance the integrity of the intestinal barrier and cut back leaky intestine.
PROBIOTA – Healthspan and Longevity
This subject would be the focus of a devoted session on the IPA World Congress + Probiota 2025 in Copenhagen, Feb. 5 to 7.
The microbiome is more and more implicated as a central participant in wholesome getting old, notably after we take a look at its impacts on immunosenescence and cognition. This session will carry collectively consultants on the reducing fringe of this analysis and attempt to perceive if and the way our microbiomes might provide a solution to enhance healthspan.
For extra info and to register, please click on HERE.
Supply: Intestine Microbes
Printed on-line forward of print, doi: 10.1080/19490976.2024.2393756
“Constant signatures within the human intestine microbiome of longevous populations”
Authors: S. Chen et al.
