Is Kourtney Kardashian’s ‘All Natural’ Ozempic Supplement Safe?

Based on a press launch from the model, the brand new complement is meant to “enhance the physique’s GLP-1 ranges, cut back starvation, promote insulin sensitivity, and assist wholesome weight administration.” The capsules are supposed to be taken as soon as every day for 3 to 6 months for finest outcomes, per the brand’s website.

Dietary supplements like Wegovy and Ozempic are GLP-1 agonists, that means they mimic GLP-1 in your physique, a naturally occurring hormone that helps regulate blood sugar, urge for food, and digestion. These medication can be found solely by prescription to deal with circumstances akin to sort 2 diabetes and weight problems.

Whereas Lemme’s new supplement has “GLP-1” within the identify, it doesn’t truly include any of the artificial hormone. So regardless of its intelligent advertising and marketing, it is not an over-the-counter model of Ozempic (and since it is a complement and never a drug, it is not as well-regulated by the FDA). As a substitute, it is made with a mix of herbs, together with lemon fruit extract, saffron extract, and pink orange fruit extract.

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Right here, we’ll dig into the analysis across the new complement’s elements, what we find out about their security and efficacy, and whether or not it is value your cash.

Components in Lemme GLP-1 Every day

The principle lively elements on this complement are lemon fruit extract (200 mg), saffron extract (176.5 mg), and pink orange fruit extract (400 mg). All are herbs which were utilized in conventional drugs practices. Here is what analysis says about their impact on weight reduction and GLP-1 ranges.

Lemon fruit extract

Lemon fruit extract is a citrus flavonoid that comes from lemon juice and peel. There’s very restricted analysis on the extract in people, however this is what we all know to this point: Final yr, a double-blind, randomized managed trial in Food Science & Nutrition discovered that Eriomin (a brand-name lemon fruit extract) had a reasonably optimistic impact on intestine flora, GLP-1 ranges, and blood sugar. However this examine was very small (solely 30 individuals made it to the tip of the 12-week interval) and all individuals had prediabetes—that means we will not say whether or not these optimistic outcomes lengthen to individuals with out prediabetes. It additionally makes no point out of how Eriomin affected individuals’ urge for food or weight.

One other July 2019 examine in Phytotherapy Research discovered comparable outcomes, in that Eriomin barely improved blood sugar and GLP-1 ranges, however this examine was additionally small (involving solely about 100 individuals) and once more solely included individuals who had prediabetes.

Each research solely adopted individuals for 12 weeks, so we do not know a lot about its long-term results. This additionally means no secure or efficient dosage has been established.

Saffron extract

Saffron is an antioxidant-rich spice that is typically utilized in holistic drugs for its purported advantages on sleep, temper points, and irritation, per a February 2022 article in Nutrients. The few research which have checked out its impact on weight found little optimistic outcomes.

Whereas one older 2010 examine in Nutrition Research suggests saffron extract might barely cut back snacking when in comparison with a placebo, it didn’t trigger important weight reduction. Extra present analysis additionally exhibits the extract has little to no impact on weight, BMI, or waist or hip circumference (although taking it did barely lower waist-to-hip ratio in some individuals), in response to a July 2022 meta-analysis of 25 research in Phytotherapy Research⁵.

Total, there’s not sufficient proof to point out that saffron might help you drop some pounds or assist management blood sugar.

Pink orange fruit extract

The third principal ingredient in Lemme GLP-1 Every day is pink orange fruit extract, aka Morosil—an extract from Silician Moro blood oranges. It is broadly marketed as a pure complement to assist facilitate weight reduction and cut back stomach fats. However the research inspecting its results are largely sponsored by corporations promoting the extract as a complement, that means there is a potential for findings to be biased.

For instance, one February 2022 double-blind, randomized managed trial in Nutrients discovered individuals with chubby who took Morosil for six months noticed diminished BMI and improved physique composition. Extra particularly, individuals misplaced about 4.2 p.c of their physique weight, in comparison with 2.2 p.c with the placebo. That mentioned, this examine was additionally small: Fewer than 200 individuals accomplished the complete six months. And it was funded by Bionap—an organization that sells Morosil—so there’s additionally a possible battle of curiosity at play.

One other January 2015 randomized managed trial in Natural Product Research had individuals with chubby (who have been in any other case wholesome) take Morosil for 12 weeks. After 4 weeks, individuals noticed a major discount in BMI in comparison with the group who took a placebo.

That mentioned, research on Morosil have been small and brief in length. Extra analysis is required to find out its long-term results, security, and perfect dosage.

It is also vital to notice that no analysis has seemed on the results of mixing these three elements, so we do not understand how they work together with each other.

Do these dietary supplements truly work? (And are they secure?)

Whereas there’s some analysis to assist that Eriomin and Morosil individually have an effect on GLP-1 pathways and result in slight weight reduction, they are not practically as efficient as conventional GLP-1 medication like Ozempic and Wegovy, which have been confirmed in scientific trials to enhance GLP-1 ranges and promote important weight reduction in individuals with chubby, per a January 2022 trial in JAMA. There’s nonetheless much more analysis to be carried out on this complement’s elements—together with their efficacy, how they work when mixed, and what’s thought-about a secure dosage.

One good factor to notice: Lemme confirmed to Nicely+Good that its GLP-1 Every day dietary supplements have been third-party examined by NSF (a good client items testing group). NSF certification ensures that what’s listed on the product label is definitely within the complement itself, and within the quantities claimed, with out extra (probably dangerous) elements like heavy metals. This sort of testing, nonetheless, doesn’t evaluation the complement’s security or efficacy.

The underside line

Finally, if you’re contemplating taking a GLP-1 complement for weight reduction or to enhance your blood sugar, begin by speaking together with your physician. They’ll decide whether or not a GLP-1 complement is secure or best for you and presumably suggest different methods to handle your weight.

Meghan Garcia Webb, MD, previously told Well+Good that there are more practical methods for weight and blood sugar administration than taking a complement, and people embrace: