Writing within the journal Frontiers in Diet, researchers from China assessed the results of omega-3 supplementation on longitudinal lipid ranges throughout being pregnant in 105 girls, in comparison with a management group of 274 members.
“[Our study] supplies new proof for the usage of omega-3 fatty acids throughout being pregnant to stop hyperlipidemia and extends the inhabitants to girls with a historical past of being pregnant losses, a high-risk group for lipid abnormalities,” the researchers wrote.
Outcomes confirmed that every day supplementation with a mushy gel capsule containing 465 mg of eicosapentaenoic acid (EPA) ethyl ester and 375 mg of docosahexaenoic acid (DHA) ethyl ester, decreased triglyceride ranges on this inhabitants.
Miscarriage and cardiovascular well being
Miscarriage impacts roughly 23 million individuals annually and has been related to heighten hyperlipidemia risk, a situation of elevated lipid ranges. This could enhance the danger of atherosclerosis and trigger cardiovascular issues, with earlier research demonstrating elevated danger of heart problems (CVD) in girls with a historical past of being pregnant loss.
Whereas widespread lipid-lowering medication like statins are averted throughout being pregnant as a result of security considerations, omega-3 fatty acids are introduced as a secure and efficient various to cut back triglycerides and enhance helpful levels of cholesterol.
Because the researchers defined, omega-3 fatty acids can restrain the production and release of very-low-density lipoprotein (VLDL) particles, whereas additionally enhancing the clearance of triglycerides in each VLDL and chylomicrons by upregulating enzymes like lipoprotein lipase (LPL).
“Nonetheless, this high-risk inhabitants has not obtained a lot consideration within the literature,” they famous, highlighting the significance of together with girls who’ve suffered being pregnant loss in analysis research.
Omega-3s throughout being pregnant
The retrospective longitudinal research divided members with earlier being pregnant losses into an omega-3 or management group. Girls within the omega-3 group had began supplementation between three and 18 weeks of gestation.
The researchers assessed the results on longitudinal lipid ranges—triglycerides (TG), whole ldl cholesterol (TC), low-density lipoprotein ldl cholesterol (LDL-C) and high-density lipoprotein ldl cholesterol (HDL-C)—utilizing generalized estimating equations (GEE).
“Supplementation with omega-3 fatty acids might considerably cut back TG ranges, but it doesn’t appear to enhance TC, LDL-C, or HDL-C ranges in pregnant girls with earlier being pregnant losses,” they reported.
Outcomes additionally confirmed that the lower in triglycerides was extra vital in girls 35 years and youthful and with a standard physique mass index (BMI), fewer being pregnant losses and better schooling ranges.
“Our analysis might have implications for lipid regulation throughout being pregnant and the wholesome being pregnant of girls who sadly skilled being pregnant losses,” the authors concluded.
They famous that future analysis ought to account for detailed knowledge on supplementation length and “embrace stringent dietary assessments to differentiate the results of omega-3 fatty acids supplementation from different dietary influences.”
Journal: Frontiers in Diet
doi: 10.3389/fnut.2024.1439599
“Impression of omega-3 fatty acids supplementation on lipid ranges in pregnant girls with earlier being pregnant losses: a retrospective longitudinal research.”
Authors: Mu, F. et al.
