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Study Links Artificial Sweetener Erythritol to Blood Clots

admin by admin
August 10, 2024
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Study Links Artificial Sweetener Erythritol to Blood Clots


Yesterday, a small new examine out of the Cleveland Clinic’s Lerner Research Institute in contrast the consequences of the artificial sweetener erythritol versus sugar and landed on grim outcomes—particularly, that erythritol elevated the danger of blood clots and coronary heart illness.

In the event you’ve ever tried to chop again in your sugar consumption with zero-calorie swaps, you’ve almost certainly had erythritol. It’s a sugar alcohol usually used to sweeten up issues like baked items, ice cream, sodas, sweet, and even protein bars with out including additional energy.

Erythritol’s security has been an ongoing debate amongst docs and customers. It’s beforehand been linked to a better danger of stroke and coronary heart assaults, however in line with the FDA, it’s GRAS (usually acknowledged as secure) to eat.

Right here, a heart specialist weighs in on the brand new analysis and breaks down the danger.

A more in-depth have a look at the examine

The examine, printed within the journal Arteriosclerosis, Thrombosis, and Vascular Biology, had an especially restricted pattern measurement—solely 20 folks. Some members got water sweetened with 30 grams of erythritol, whereas others drank water sweetened with 30 grams of standard sugar. Thirty minutes afterward, everybody had their blood drawn. The members who drank the erythritol-sweetened beverage confirmed excessive ranges of blood platelet exercise (clotting), however there was no change for the members who drank sugar water.

Associated Tales

“Erythritol is poorly metabolized by the physique, which means that it’s exhausting on your physique to do away with it, particularly when you eat it in giant portions,” says Nikki Bart, MD, a coronary heart failure and coronary heart transplant heart specialist on the Victor Chang Cardiac Analysis Institute. “There may be an rising sign right here that it might not be as secure as beforehand believed.”

However, Dr. Bart provides: “The outcomes must be taken with the caveat that the whole variety of folks studied is small.” Nonetheless, this is not the primary examine to hyperlink erythritol with problematic results. “The identical group printed a population-based examine final yr linking larger ranges of erythritol to cardiovascular occasions in 4,000 folks,” she notes.

Dr. Bart says given how restricted the examine is, extra analysis linking erythritol to cardiovascular occasions is important. It’s additionally necessary to notice that the examine members got so much of erythritol in a single sitting (greater than you’ll sometimes get from consuming one zero-sugar soda or consuming one erythritol-sweetened protein bar), which possible affected the outcomes.

What does this imply for individuals who monitor their blood sugar and select zero-sugar choices?

Though extra analysis must be achieved to attract any agency conclusions, it might be finest to restrict erythritol and different synthetic sweeteners in your food regimen, particularly when you dwell with power circumstances like diabetes, hypertension, and coronary heart illness.

Basically, “sugar and sugar substitutes must be restricted and prevented the place doable,” Dr. Bart says. “Sugar substitutes themselves have been linked to weight problems, diabetes, and different well being circumstances. Plus, they’re synthetic and may be pro-inflammatory.”

The best choice to sweeten meals, she says, is vegetables and fruit, which have added dietary advantages.

What can folks do to decrease their danger of blood clots?

Past limiting erythritol and different synthetic sweeteners, Dr. Bart says sustaining a wholesome weight is most necessary for lowering blood clot danger.

In keeping with the Mayo Clinic, blood clot danger may also be lowered by doing the next:

  • Keep away from sitting for lengthy intervals of time
  • Follow every day motion, even when it’s only a mild stroll
  • Keep hydrated
  • You probably have hypertension, take steps to lower it
  • Quit smoking

The underside line is, there’s so much we nonetheless don’t know concerning the physique’s response to erythritol. As a basic rule of thumb, although, complete, unprocessed meals like contemporary vegetables and fruit are undisputedly higher than something chemically made. However extra investigating needs to be achieved to find out the long-term results of synthetic sweeteners on well being.


Effectively+Good articles reference scientific, dependable, current, strong research to again up the data we share. You’ll be able to belief us alongside your wellness journey.


  1. Witkowski, Marco, et al. “Ingestion of the Non-Nutritive Sweetener Erythritol, however Not Glucose, Enhances Platelet Reactivity and Thrombosis Potential in Wholesome Volunteers.” Arteriosclerosis Thrombosis and Vascular Biology, 8 Aug. 2024, https://doi.org/10.1161/atvbaha.124.321019. Accessed 9 Aug. 2024.




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