Commercially out there since 2010 and bought in South Korea, Europe, Canada and america, the mix is a mixture of pure Cynanchum wilfordii, Phlomis umbrosa and Angelica gigas.
EstroG-100, which was invented and is manufactured by Naturalendo Tech in South Korea, has seen its recognition rise, as is mirrored by the monetary success of the ingredient’s U.S. distributor, CK Components. The distributor has skilled a yr over yr doubling of progress for its menopause choices. The listing of U.S. manufacturers which have included EstroG-100 consists of Physician’s Finest and California Gold Diet.
In keeping with Verified Market Reports, the menopause complement market measurement was valued at greater than $100 billion in 2023 and is projected to succeed in over $140 billion by 2030.
“EstroG-100 is the most secure, greatest studied and most multi-symptom ingredient for menopause symptom aid,” stated Colleen Madden, vice chairman of innovation at CK Components. “Once I have a look at the formulation which are in the marketplace for thus many even massive firms, they appear to deal with so few signs. It looks like many firms suppose that sizzling flashes are the factor, and when you may have sizzling flashes, you may be depressing. However as soon as you do not have sizzling flashes anymore, you may be nice. That is not the case.”
EstroG-100 doesn’t have an effect on estrogen or its receptors. Its phytochemicals, together with phenols, iridoids and coumarins, act on mind neurotransmitters equivalent to serotonin and adenosine, and on inflammatory components and oxidative stress management. Whereas EstroG-100 does assist enhance sizzling flashes, it additionally helps with different menopausal signs, equivalent to temper issues, sleep issues and fatigue to enhance general high quality of life, in keeping with 5 human medical research on EstroG-100.
From conventional use to synergistic results
The mix utilized in EstroG-100 is predicated on a protracted custom of Chinese language and Korean natural drugs.
Information for Phlomis umbrosa root dates again to the early 1600s when it was consumed to deal with decrease again ache, illness after childbirth, sterility and fracture. In Korean conventional drugs, it was additionally used to deal with ailments after baby supply, ache, pores and skin restoration and muscle and bone points.
Angelica gigas has been utilized in Korea for roughly 400 years and presumably even longer in China for being pregnant, menstrual issues and premenstrual syndrome, whereas Cynanchum wilfordii has been consumed for near 200 years in Korea and China for vitamin, tonic, blood and renal well being.
The mix of the three vegetation weren’t administered for peri and menopausal signs till modern researchers found their synergistic results.
Extra lately, three potential, randomized, double-blind, placebo-controlled medical research printed in 2022 confirmed vital enchancment in climacteric signs in girls after three months of taking EstroG-100 as in comparison with a placebo. Carried out in Korea, the second of those research demonstrated enchancment in 12 typical menopausal signs amongst members. That very same yr, a U.S. examine confirmed a statistically vital enchancment of 62% within the Kupperman menopausal index (KMI), a check for assessing the standard of lifetime of menopausal girls by way of a rating.
These medical research haven’t reported any related negative effects or influence on physique weight, BMI, serum estradiol or follicle stimulating hormone (FSH). Additional research shows that the EstroG-100 extract has “no binding affinity to estrogen receptors and no stimulatory results on the expansion of estrogen-sensitive tissues equivalent to feminine breast cells and endometrium.”
Sexual well being
A 2023 potential, single-center, single-arm, interventional examine in 60 feminine topics with menopause and average‑to‑extreme signs evaluated the consequences of EstroG‑100 consumed twice each day for 12 weeks.
Total, not less than 96% of sufferers have been happy with the therapy. Amongst a few of the noteworthy findings was that girls went from 83% dissatisfied of their “curiosity in intercourse” to 100% happy or extraordinarily happy in it after taking the complement.
Nevertheless, addressing sexual well being signs shouldn’t be all the time a precedence for firms promoting substances and dietary supplements for menopause, Madden stated.
“This examine is not actually about sexual well being solely, however I’d by no means seen [sexual interest] as a part of a menopause examine,” she added. “It was one of many issues that caught out to me as very indicative of nice outcomes. To me, it encapsulates this general high quality of life story. In order that’s why I believe that it is worthwhile speaking about and stating to folks as a result of it is one thing that is not mentioned.”
Supply: Journal of Mid-life Well being
doi: 10.4103/jmh.jmh_220_23
“Analysis of Efficacy and Security of EstroG‑100 in Assuaging Menopausal Signs in Postmenopausal Ladies in India: A Potential, Single‑heart, Single‑arm, Interventional Research”
Authors: Hepzibah Kirubamani et al.
