Writing within the Journal of Meals & Drug Evaluation, scientists report that animals fed the Citrus depressa peel ethanol extract (CDEE) and a high-fat eating regimen additionally had much less fats tissue ranges and higher levels of cholesterol in comparison with animals solely fed a high-fat eating regimen.
Evaluation of the intestine microbiota revealed that the citrus extract-fed animals additionally had greater abundance of Limosilactobacillus reuteri in comparison with non-supplemented animals.
“L. reuteri is a well-studied probiotic bacterium that confirmed that CDEE might need a prebiotic-like impact to forestall lipid accumulation due to its flavonoid content material,” wrote scientists from Chung Yuan Christian College, the Nationwide Yang Ming Chiao Tung College and the Nationwide Ilan College.
The present consensus definition from the Worldwide Scientific Affiliation for Probiotics and Prebiotics (ISAPP) is: “A substrate that’s selectively utilized by host microorganisms conferring a well being profit.”
Examine particulars
The Taiwanese researchers reported that the Citrus depressa peel extract was discovered to comprise totally different flavonoids together with hesperidin, nobiletin, tangeretin, sinensentin, 5-demethyl-nobiletin and 5-demethyltangeretin.
They then examined this extract in lab mice fed a high-fat eating regimen (HFD) and in contrast the outcomes to lab mice solely fed the HFD. After 12 weeks of supplementation, the researchers discovered that the HFD-CDEE group had a considerably decrease (0.8%) weight acquire in comparison with the HFD solely animals.
As well as, the HFD-CDEE group had considerably decrease ranges of whole ldl cholesterol, HDL- and LDL-cholesterol, however additionally they had greater ranges of triglycerides than the HFD-only mice.
No vital variations had been detected for ranges of AST (aspartate aminotransferase), stated the researchers. “AST is a vital liver toxicity index; thus, the end result obtained proved that mice administered with CDEE didn’t expertise liver harm,” they said.
A rise within the abundance of L. reuteri was additionally reported, in comparison with the HFD group.
“On this examine, CDEE demonstrated prebiotic potential by reacting with L. reuteri to ameliorate the hostile results brought on by an HFD,” the researchers wrote, with further evaluation revealing that the “bacterial composition of the HFD-CDEE teams had the next abundance associated to carbohydrate transport and metabolism and a decrease abundance associated to lipid transport and metabolism in contrast with the HFD group.”
Supply: Journal of Meals & Drug Evaluation
2024; 32(2): 213–226, doi: 10.38212/2224-6614.3504
“Citrus depressa peel extract acts as a prebiotic to cut back lipid accumulation and modulate intestine microbiota in overweight mice”
Authors: Z-Y. Su et al.
