“[O]ur examine demonstrates that the supplementing with 2,000 mg/day of entire Ganoderma lucidum extract for eight weeks positively regulates the expression of genes related to activating Th1, Th2 and Th17 cell profiles,” the examine authors from Brazil wrote. “The shift towards a Th2 profile […] suggests a predominance of an anti-inflammatory response.”
Immunosenescence
As individuals age, they expertise immunosenescence, which is a lower in immune perform, each innate and adaptive. The perform, activation and differentiation of T lymphocytes has been proven to be impaired within the aged, resulting in an immune imbalance.
Growing old can also be related to a persistent low-level state of irritation. Adaptive immunity is mediated by each T and B lymphocytes, and pure growing old decreases T cell manufacturing. Thus, the authors sought to check the consequences of Ganoderma lucidum on immunosenescence within the context of T lymphocyte perform.
The mushroom has an immunomodulatory capability through which it could assist improve T and B lymphocytes. Prior literature has additionally proven it to have antiviral and antibacterial results resulting from its modulation of the immune system; it’s also a wealthy supply of polysaccharides which may modulate adaptive and innate immune responses.
“Subsequently, Ganoderma lucidum dietary supplements might be essential in correcting the immunosenescence-associated immune lymphocyte imbalance,” the examine famous.
Research particulars
The authors used remoted elements of Ganoderma lucidum, primarily beta glucans, which may stimulate leukocyte capabilities and have the potential for antiaging therapeutic advantages.
For this examine, 39 girls between the ages of 60 and 80 have been divided into two teams: one consumed a placebo and the opposite 2,000 mg of Ganoderma lucidum for eight weeks. Blood and urine have been collected and analyzed earlier than and after the eight-week interval. Physique mass index, lymphocytes and gene expression have been analyzed.
Physique mass composition didn’t change in both group. Following the supplementation interval, sure gene expressions, corresponding to IL6 and TNF alpha, have been greater for individuals within the complement group. IL-2 gene expression was additionally elevated on this group after eight weeks, suggesting the cytokine could mediate a regulatory mechanism.
“This noticed improve in lymphocyte proliferation and the related upregulation of IL-2 gene expression in Ganoderma lucidum post-supplementation could signify a constructive impression of Ganoderma lucidum on the TCR signaling pathway, contributing to enhanced immune response and regulatory mechanisms,” the authors wrote. “Subsequently, our knowledge counsel that Ganoderma lucidum could regulate different co-stimulatory molecules concerned in lymphocytic proliferation.”
Supply: The British Journal of Diet
2024, Could 27. doi: 10.1017/S0007114524001144
“Ganoderma lucidum dry extract supplementation modulates T lymphocyte perform in older girls”
Authors: Iser-Bem, P. et al.
