Findings from a human intervention research indicated that 14 days of supplementation with each three or six grams of the partially hydrolyzed guar gum led to important will increase in Verrucomicrobia and Akkermansia in wholesome topics.
“This research demonstrated a big prebiotic impact for Sunfiber at a decrease dose than beforehand proven,” mentioned the research’s lead researcher, Joanne Slavin, PhD, RD, a world-renowned fiber skilled on the College of Minnesota. “The numerous will increase in Akkermanisa are a novel discovering and new profit space for shoppers.”
The findings are revealed in Utilized Microbiology.
Prebiotics
Prebiotics are outlined by the Worldwide Scientific Affiliation for Probiotics and Prebiotics (ISAPP) as, “A substrate that’s selectively utilized by host microorganisms conferring a well being profit”. (Gibson et al., 2017)
Earlier research with Taiyo’s Sunfiber have supported a prebiotic impact for doses of 5 g per day and upwards, however the brand new research means that prebiotic advantages might also be noticed at decrease doses.
“Sunfiber is in style partly due to its efficacy, versatility, ease of use and a number of sought-after certifications,” mentioned Scott Smith, president of Taiyo Worldwide. “This new analysis opens the doorways to much more formulation prospects, now that we all know Sunfiber’s super potential to advertise digestive well being even at 3 g doses.”
Examine particulars
Prof. Slavin and her co-workers recruited 33 wholesome folks (17 males and 16 ladies) to take part of their randomized, double-blind, placebo-controlled crossover research. The volunteers have been randomly assigned to one in all three teams: 3 or 6 g per day of Sunfiber or a placebo for 14 days. Every intervention was adopted by a two week washout interval (a low fiber interval) earlier than the volunteers crossed over to the opposite teams.
“Within the current research, each Verrucomicrobia and Akkermansia elevated with PHGG supplementation,” the researchers wrote. “The mucin-degrading microbe, Akkermansia muciniphila, is a micro organism of the phylum Verrucomicrobia, and it’s present in greater concentrations in wholesome people. It has been proven that the focus of Verrucomicrobia current in people with weight problems is decrease, and decreased concentrations of Verrucomicrobia might even function an indicator of insulin resistance or kind 2 diabetes (T2DM).”
Prof. Slavin and her co-workers added that the abundance of A. muciniphila was considerably decrease in folks with GI circumstances corresponding to IBD, “suggesting that the decreased focus of this micro organism might operate as an indicator of dysbiosis,” they mentioned.
Sunfiber supplementation on the 6 g per day stage additionally led to decreases in salivary cortisol ranges, indicating a probably optimistic have an effect on the physique’s stress response, the research famous.
Nonetheless, it additionally reported that the low dose group had important decreases in Faecalibacterium, micro organism with anti-inflammatory exercise and an indicator of a wholesome intestine.
“The outcomes of a earlier research, whereby topics consumed 5 g PHGG as much as 3 times every day, confirmed a subsequent enhance within the stage of Faecalibacterium,” the researchers wrote.
“This will likely recommend that greater doses of PHGG are wanted to extend the focus of Faecalibacterium. Additional analysis must be carried out to discover the impression of low dose PHGG on Faecalibacterium.”
The researchers concluded: “The current research demonstrated that even small doses of PHGG, as little as 3 g, can affect the composition of the human intestine microbiome in wholesome topics together with optimistic shifts in useful microbes. Particular person variability within the human intestine microbiome poses challenges in figuring out how selective modifications to bacterial taxa might end in well being outcomes.
“Extra analysis must be centered on how modifications within the intestine microbiome composition are related to ensuing GI signs and different physiological advantages.”
Supply: Utilized Microbiology
2024, 4(2), 720-730; doi: 10.3390/applmicrobiol4020049
“The Dose Response Results of Partially Hydrolyzed Guar Gum on Intestine Microbiome of Wholesome Adults”
Authors: M. Edelman, et al.
