The Italian probiotic producer’s mixture of L. plantarum-PBS067, L. rhamnosus-LRH020 and B.lactis-BL050 bacterial strains have been proven to exhibit antimicrobial exercise in opposition to urogenital infections and bacterial vaginosis and restore the vaginal microbiota.
It has additionally been discovered to enhance the relative abundance of Lactobacillus to scale back irritation and reverse dysbiosis; a typical prevalence in ladies’s well being situations similar to menopause.
The skilled judging panel mentioned the product was chosen due to its ‘clear and exact market positioning and its steady, ongoing drive to boost the physique of scientific proof supporting the product’s claims.’
Silvia Castegnara, product supervisor at SynBalance Probiotics informed NutraIngredients on the awards ceremony in Geneva final week: “Successful this award is a marker of validation of the significance of microbiome modulation in ladies’s well being.”
Restoring vaginal microbiota
Menopause ends in a significant decline in estrogen and progesterone ranges, resulting in elevated incidence of irritating genital symptoms.
Estrogen is essential for glycogen manufacturing which offers nutrients for lactobacilli growth, which helps keep vaginal homeostasis by varied mechanisms. The discount of lactobacilli on account of oestrogen decline can result in a rise in pathogenic species, and subsequently a rise in the vaginal pH.
Research carried out by SynBalance discovered that Femme was efficient in the prevention of bacterial vaginosis (BV) recurrences, improved the restoration of a balanced microbiota, and promoted the expansion of useful lactobacilli.
The probiotics have been proven to help the formation of a probiotic monolayer and an acidic microenvironment, which prevents pathogen adhesion, but additionally inhibits pathogen cell development by co-aggregation with G. vaginalis, E. coli and C. albicans.
SynBalance additionally realized the importance of addressing a vital and ignored demographic of menopausal ladies, Castegnara famous.
A recent clinical trial carried out in 50 menopausal members, confirmed that supplementation led to vital enhancements throughout varied parameters such as a 50% enhancement within the Vaginal Well being Index (VHI) rating and substantial reductions in inflammatory cytokine ranges.
As Castegnara defined, Synbalance’s objective with Femme is to give attention to ladies’s well being past remedy, as prescribed options similar to antibiotics can disrupt the vaginal ecosystem.
Femme is designed to counteract this, she famous, recommending that probiotics can help and replenish the vaginal microbiota, which will help keep a wholesome steadiness and obtain long-lasting constructive outcomes.
