Writing in Frontiers in Immunology, scientists from the French Nationwide Institute of Well being and Medical Analysis (Inserm) reported that supplementation with F. duncaniae (previously known as F. prausnitzii) led to much less extreme illness, a decrease pulmonary viral load and decrease ranges of lung irritation, in comparison with the management group.
As well as, the info confirmed that the dwell micro organism (probiotic) was stronger than the pasteurized type (postbiotic) for enhancing the outcomes related to flu.
“Our current outcomes recommend that F. duncaniae—a serious, canonical, butyrate-producing human commensal—may function a novel subsequent era probiotic in opposition to viral respiratory illnesses,” they wrote.
Probiotics and the flu
The research provides to a rising physique of science supporting probiotic supplementation and improved outcomes regarding respiratory tract infections.
Certainly, a 2019 paper revealed in Frontiers in Pharmacology indicated that probiotics might cut back the period of flu-like respiratory tract an infection, using antibiotics and missed days at work, all of which might translate into over $1 billion of prices financial savings in the US.
5–20% of the inhabitants could have at the least one RTI yearly
Within the US, this results in:
31.4 million outpatient visits,
3.1 million hospitalized days,
41,000 deaths yearly.
Research particulars
For the brand new research, the Inserm scientists divided lab mice into 5 teams: One group obtained no intervention, one group was contaminated with influenza A however no different intervention, and the three different teams obtained dietary supplements of dwell F. duncaniae (A2-165 or I-4574 strains) or pasteurized A2-165 for 5 days earlier than an infection with influenza A.
Outcomes confirmed that each dwell strains had been related to partial safety in opposition to flu, with much less physique weight reduction, a decrease viral load within the lungs, and decrease ranges of pulmonary and intestine irritation, the researchers reported.
The dwell type carried out considerably higher than the pasteurized type.
“You will need to word that supplementation with F. duncaniae additionally alleviated systemic secondary bacterial infections,” they added. “These protecting results had been related to a change in intestine microbiota composition and an augmentation of SCFA [short chain fatty acid] ranges in diseased animals.
“We conclude that F. duncaniae may function a novel subsequent era probiotic in opposition to acute viral respiratory illnesses.”
Supply: Frontiers in Immunology
2024, Quantity 15, doi: 10.3389/fimmu.2024.1347676
“Faecalibacterium duncaniae as a novel subsequent era probiotic in opposition to influenza”
Authors: L. Chollet, et al.
