Information revealed in Frontiers in Vitamin indicated that 12 weeks of supplementation with 200 micrograms per day of selenium additionally elevated complete antioxidant capability and lowered ranges of MDA (malondialdehyde), a marker of oxidative stress.
“To one of the best of our data, this was the primary randomized managed trial (RCT) to look at the impact of selenium supplementation on medical and physiological outcomes of sufferers with migraine,” the researchers wrote.
Selenium
Selenium is a necessary micronutrient and is taken into account to be an antioxidant. The mineral is included in 25 selenoproteins within the physique, with various roles together with immune help, thyroid perform and wholesome sperm. The difficulty for selenium, as for different vitamins, is you can get an excessive amount of of an excellent factor.
Information from potential research have reported potential threat reductions for quite a lot of cancers for selenium, and it’s the solely mineral that qualifies for a Meals and Drug Administration (FDA)-approved certified well being declare for normal most cancers discount incidence.
A review paper by Joyce McCann and Bruce Ames from the Vitamin and Metabolism Middle at Kids’s Hospital Oakland Analysis Institute in Oakland (CHORI) indicated that reasonable deficiency in selenium could have long-term detrimental results (FASEB Journal, 2011, Vol. 25, pp. 1793-1814).
The brand new research by scientists from Isfahan College of Medical Sciences means that selenium may additionally have a job to play in migraines, linked to its antioxidative results.
Research particulars
The Iranian researchers recruited 72 individuals who undergo from migraines and randomly assigned them to obtain both selenium dietary supplements (200 micrograms per day within the type of selenomethionine) or placebo for 12 weeks.
Outcomes confirmed that not solely did complete antioxidant capability improve and MDA ranges lower, in comparison with placebo, however there was additionally a major discount in ranges of nitric oxide (NO).
“NO, an oxidant vasodilator, is elevated within the platelets, urine and plasma of sufferers with migraine, which participates in trigeminovascular irritation and likewise accelerates ache within the central nervous system,” the researchers defined.
“Furthermore, elevated ranges of lipid peroxidation metabolites akin to MDA have been noticed in migraineurs throughout headache assaults. For that reason, enhancements noticed relating to the frequency and severity of complications may be defined by assuaging neurogenic irritation and oxidative stress.”
The information additionally revealed that the frequency and severity of complications decreased within the selenium group, however no enhancements had been reported in the course of complications.
Moreover, no variations between the teams had been noticed for psychological well being measures, akin to melancholy, nervousness and misery.
The researchers known as for future medical trials to duplicate these outcomes and likewise to elucidate the optimum dosage for selenium supplementation.
Supply: Frontiers in Vitamin
2024, Quantity 11, doi: 10.3389/fnut.2024.1369373
“The impact of selenium supplementation on oxidative stress, medical and physiological signs in sufferers with migraine: a double-blinded randomized medical trial”
Authors: A. Balali et al.
